Therapeutics - HIV 5
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What type of drug is Emtricitabine-Emtriva?
What type of drug is Abacavir+Lamivudine - Epzicom?
What type of drug is Emtricitabine+Tenofovir DF – Truvada?
What type of drug is Lamivudine+Zidovudine – Combivir?
What type of drug is Nevirapine – Viramune?
What type of drug is Delavirine – Rescriptor?
What type of drug is Maraviroc?
CCR5 co-receptor antagonist (Fusion Inhibitor)
What are the Fusion inhibitors?
Maraviroc and Enfuvirtide
What is the generic name for Fuzeon?
What is the brand name for Enfuvirtide?
What is the brand name for Maraviroc?
What is the generic name for Selzentry?
What type of drug is Efavirenz – Sustiva?
What type of drug is Atripla (tenofovir + emtricitabine + efavirenz)?
What type of drug is Etravirine – Intelence?
What type of drug is Rilpivirine – Edurant?
What type of drug is Complera (tenofovir + emtricitabine +rilpivirine)?
Atazanavir has better or worse Bioavailability with food?
How is Atazanavir metabolized?
Metabolized by P4503A inhibitor/substrate
What are the SE for Atanazivir?
hyperbilirubinemia – (jaundice); HA; rash; GI symptoms; 1st degree A-V block; hyperglycemia; fat maldistribution
What is the preferred boosted-PI by DHHS guidelines?
Daranavir will be used along with ___________.
Daranavir should be given with or without food?
Daranavir can be used with what type of HIV virus?
Used for wild-type and PI-resistant virus
What are the SE of Daranavir?
Hepatitis; S-J syndrome; TEN; HA (15%); N (18%); diarrhea (20%)
Contains sulfa moiety – rash
How is Daranavir metabolized?
Fosamprevavir is effected by food in what way?
No food effect
What CYP interactions does Fosamprevavir have?
What are the SE of Fosamprevavir?
rash 19% S-J syndrome; headache; hyperlipid; fat maldistribution;
Sulfa moiety – rash
Indinavir has what CYP interaction?
Indinavir has what SE?
Nephrolithiasis (kidney stones); GI intol; hyperbilirubinemia; hyperlipid; hyperglycemia; fat maldistribution; headache; blurred vision; rash; red. PLTs
Lopinavir+Ritonavir should be taken with or without food?
Mod. Fat meal elevates AUC 48% and 80% (caps/solution)
What CYP effects does Lopinavir+Ritonavir have?
What SE does Lopinavir+Ritonavir have?
GI intol; hyperlipid; elevated LFTs; hyperglycemia; fat maldistribution
Nelfinavir should be taken with or without meals?
Concs. Increase 2-3 fold – take w/meals
Nelfinavir has what CYP effects?
Nelfinavir has what SE?
diarrhea; hyperlipid; hyperglycemia; fat maldistribution; elevated LFTs
Tipranavir is not recommended in what group and why
Not recommended in tx-naïve pts.
Use for People to fall back on if they develop resistance
Therapeutics - HIV 5
Therapeutics - HIV