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Mawad
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Ehrlichia canis
Cells infected-
Vector-
Lab Findings-
Therapy-
- Cells infected- monocytes
- Vector- brown dog tick
- Lab Findings- Thrombocytopenia (acute and subclinical), pancytopenia w/ non-regenerative anemia (chronic)
- Therapy- Tetracycline/doxycycline
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German shepherds are predisposed to ____________ infection because of defective cellular immunity.
Ehrlichia canis
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What are the clinical syndromes associated with Ehrlichia canis infection?
acute, subclinical, and chronic
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What is the hallmark of chronic Ehrlichia canis infection?
pancytopenia (nonregenerative anemia, neutropenia, and thrombocytopenia)
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In acute Ehrlicia canis infection, the organism replicates in host ________, resulting in _______.
macrophages; vasculitis
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In acute Ehrlichia canis infection, thrombocytopenia is due to... (3)
immune-mediated destruction, vasculitis, and splenic sequestration
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In chronic Ehrlichia canis infection, decreased production of hematopoietic cells is due to... (3)
immune-mediated destruction, ste cell depletion, and altered BM microenvironment
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Ehrlichia ewingii
Disease-
Cells infected-
Vector-
Lab Findings-
Therapy-
- Disease- canine granulocytic ehrlichiosis
- Cells infected-granulocytes
- Vector- lone star tick
- Lab Findings- thrombocytopenia, nonregenerative anemia, inclusions in granulocytes, eosinopenia, lymphopenia, neutrophilia
- Therapy-tetracycline
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Ehrlichia chaffeensis
Disease-
Cells infected-
Vector-
Lab Findings-
- Disease- Humon monoccytic ehrlichiois (dogs are reservoir)
- Cells infected- mononuclear cells
- Vector- ticks (Amblyomma americanum)
- Lab Findings- thrombocytopenia, lymphocytosis
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Feline ehrlichiosis
Cells infected-
Vector-
Lab Findings-
Therapy-
- Cells infected- monocytes
- Vector- ticks
- Lab Findings- thrombocytopenia, nonregenerative anemia, morulae in monocytes
- Therapy- Doxycycline
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Transmission of the 3 anaplasma phagocytophilum (all 3 strains) is by _________.
Ixodes ticks (ften co-infected with Lyme disease agent)
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Anaplasma phagocytophilum (in Equines)
Cells infected-
Vector-
Lab Findings-
Therapy-
- Cells infected-neutrophils and eosinophils
- Vector- Ixodes ticks
- Lab Findings- thrombocytopenia, leukopenia
- Therapy- Oxytetracycline
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When diagnosing equine granulocytic ehrilichiosis, first rule out...
EIA with Coggins test (very similar symptoms)
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The pathogenesis of equine granulocytic ehrlichiosis involves ________.
vasculitis
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Anaplasma phagocytophilum (in Canines)
Cells infected-
Vector-
Lab Findings-
Therapy-
- Cells infected- neutrophils and eosinophils
- Vector- Ixodes tick
- Lab Findings- thrombocytopenia, nonregenerative anemia, lymphopenia
- Therapy- tetracycline
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Anaplasma phagocytophilum (in felines)
Cells infected-
Vector-
Lab Findings-
Therapy-
- Cells infected- neutrophils and eosinophils
- Vector- Ixodes tick
- Lab Findings- thrombocytopenia, hyperglobulinemia
- Therapy- tetracycline
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Anaplasma phagocytophilum (in bovines)
Cells infected-
Vector-
Lab Findings-
- Cells infected- neutrophils, eosinophils, and monocytes
- Vector- Ixodes tick
- Lab Findings- thrombocytopenia, neutropenia
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Neorickettsia risticii
Disease-
Cells infected-
Vector-
Lab Findings-
Therapy-
- Disease- Equine monocytic ehrlichiosis
- Cells infected- monocytes and macrophages
- Vector- trematode (caddis flies and mayflies)
- Lab Findings- thrombocytopenia, leukopenia (maybe with rebound leukocytosis)
- Therapy- oxytetracycline
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What are the clinical sign of equine monocytic ehrlichiosis?
diarrhea, colic, laminitis
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Neorickettsia helminthoeca
Disease-
Cells infected-
Vector-
Lab Findings-
Therapy-
- Disease- Salmon poisoning in dogs
- Cells infected- monocytes
- Vector- trematodes (ingestion of infected salmon)
- Lab Findings- lymphopenia, throbocytopenia
- Therapy- tetracyclines
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Leishmania infantum (L. donovani-less common)
Disease-
Cells infected-
Vector-
Lab Findings-
- Disease- Leishmaniasis in dogs
- Cells infected- macrophages
- Vector- female sandflies (take blood meal for reproduction)
- Lab Findings- thrombocytopenia, hypergammaglobulinemia, immune-mediated hemolysis, azotemia
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There is an increased risk in _________ for infection with Leishmania infantum.
foxhounds
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With Leishmania infantum infection, there is ___________ and ____________ clinical signs, and circulating immune complexes may cause... (3)
lymphadenopathy and hepatosplenomegaly; vasculitis, arthritis, and glomerulonephritis (acute inflammation of the kidney, typically caused by an immune response)
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Clinical signs of infection with Leishmania infantum include.... (3)
cutaneous lesions, epistaxis, diarrhea
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Hepatozoon americanum
Disease-
Cells infected-
Vector-
Lab Findings-
Therapy-
- Disease- canine hepatozoonosis
- Cells infected- neutrophils and monocytes
- Vector- ticks
- Lab Findings- marked neutrophilic leukocytosis, nonregenerative anemia
- Therapy- anticoccidial drugs
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