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Innate Imunne system:
Also known as non specific is the first line of defense. We were born with it, doesn't have antibodies.
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Inflammatory response: innate immunity
second line of defense to injury or infection immediate broadly specific.
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Adaptive immunity:
Third line of defense in response to antigen exposure, very specific, lymphocyte system, t and b lymphocytes
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Vascularized tissue:
vasodilaton
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Inflammation physiologic:
- localization: prevents spreading
- REcruitment
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Inflammation pathologic:
- acute inflammation save your life
- chronic can damage tissue 2 weeks death
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Leukocyte: 1st innate
1st responder, most abundant, phagocytosis, chemotaxis, 1st 24 hours, not specific, diapedisis, pus.
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Macrophage: monocyte
after 24 hours, diapedisis, before no inflammation.
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Mast cell:
- proinflammatory, produces histamine, most powerful cell. degranulation, constriction of smooth muscle, they activate ARACHIDONIC ACID
- leukorienes-increase inflammation, prostaglandins-increase cap permeability, smooth muscle constriction and pain, thromnoxane-platelet avtivation, prostacyclines inhibits all the above
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Degranulation:
release antimicrobial cytotoxic molecules
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Euosinophils :
Creates and enzyme to destroy histamine "ANTIinflammatory", fights parasites.
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Natural Killer cells:
designed to kill self cells, Virus kills the whole cells, they do not require a flag(M.H.C.)
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Cytokines are protein released by another cel: cell signaling
- These are proteins released:
- Interleukins: pyrogen fever inducing substance
- interferon: viral infections
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Plasma Protein Sytems essential to inflammatory response: Complement
Sprinkles liver produces compliment adheres to external surfaces of all cells. A way to signal your immune system activates cells to die.
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Coagulation:
making blood clot
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Kinin:
is another pain simulator
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Interferons:
help with viral infections, local manifestation, 4 cardinal signs, exudative-fluids out of your pipes, Serous-watery early acute, Fibrous-thick,clotted more advanced, Purulent-Nasty
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Exogenous:
in bacteria infections
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Leukocytosis:
High white blood cell count in leukocytes
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Adaptive Immunity: passive natural
- fetus palcenta antibodies IGG
- Breastmilk antibodies IGA
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Active Natural:
Chickenpox exposed and make antibodies yourself.
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Passive artificial
antibody therapy specific antibody to kill rabies
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Active Artificial
vaccinations antigens and develop antibodies so you can have memory,
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Active
self produce antibodies sou you can have memory
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Passive
when antibodies are transferred.
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Antigen
is a forein substace to the body that then produces and antibody to fight it
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B CEll
MHC-2 connects to CD4, b-cell will differentiate into plasma cell to make antibodies or memory bcells
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T-cell
MHC1 or MHC2 differentiate into 3 cells, memory t cells, th, or cytotoxic
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