cancer

cancer cells activate _______ to restore and maintain ____________ so cells can divide over and over again

wasting, emaciation, anorexia, and early satiety is what?

micro RNA's that can act as ______ or tumor suppressor genes is epigentics

most relevant carcinogens produced by

addition of methyl group to cystine ring to silence tumor suppressor genes and is astagein epigenetics

smoke exhaled by the smoker is?

repletion of erythrocyte building block depletion or destruction of bone marrow where RBC's are synthesized leads to what is cancer patients?

repletion of what and destruction of what causes anemia?

at ends of each chromosome, block unlimited cell division

what is the most common mutation?

ACTH suggests what?

increases risk for mestotheilioma and lung CA

Radon from decay of _____ trapped in houses

how can CA cells invade into lympth and vascular system?

what is the first step in metastasis

CA cells must overcome multiple ______ ______ to be able to spread, survive and reproduce

in carcinogenesis methylation of DNA shuts off genes without mutation is known as what?s

in carcinogenesis inactivates tumor suppressor genes by loss of what?

ability to develop in particular ways related to the environment setting

loss of cellular differentiation or specialization loses ability to function and control its growth and division

independence form normal cellular controles

_____ _______ increase circulating levels of insulin and increase insulin like growth factor biologic activity

pain related to necrosis, direct pressure or obstruction occurs in what?

what has to be accessible for surgical therapy to take place for a cancer patient?

ability to develop in particular ways related to the enviroment or setting

in radiation the challenge is to eradicate ______ cells w/o producing excessive ________ andaroid damage to normal structures

chemotherapy's main goal is to kill cells that are undergoing what?

examples of pneotypic effects of epigeneric changes

histone modification of _______ is a stage of epigentics

tumor cell markers are produced by

AFP suggests what?

benign fibrous connective tissue?

benign lymphoid tissue

benign nerve tissue

benign glandular epithelial tissue

malignant + glandular epithelial tissue

preinvasive epithelial tumors of glandular or squamous cell origin

malignant fibrous connective tissue

malignant + lymphoid tissue

malignant nerve tissue

tumor cell marker are found on tumor plasma membranes or in

PSA suggests what?

tumor supressor genes produce ______ that normally inhibit cells division or oppose action of an oncogene that can transform or normal cell into a cancerous cell when inherited or activated by a virus

in carcinogenesis inactivates tumor suppressor genes by loss of what?

unlimited lifespan continue to devide

______ _______ period preceds onset of adult cancer

variable size and shape

loss of cellular differentation or specialization loses ability to function and controls its growth and division

what puts you at risk for more cancer?h

toxic, mutogenic, and carcinogenic chemicals

changes in genes collaborative with environmental lifestyle factors to cause development of CA. changes are ______ and _________ heritable

hyperglycemia, cytokines IL-6, interferon and TNF causes what?

smoke from the burning end of the cigarett is

what is the most important cause of cancer

phenotypic effects of ___________ changes during development may need long latency periods

what follows anemia in cancer patients

what has to be accessible for surgical therapy to take place for a cancer patient?

P53 gene causes resistance to _______ or self destruction mechanism

goal is to kill cells that are undergoing mitosis and cytokinesis

pain related to necrosis, direct pressure or obstruction occurs in what?

in carcinogenesis unmasks mutations in what?

independence from normal cellular controls

______ ______ increase circulating levels of insulin and increase insulin like growth factor biologic activity

as diversity increases, number of cells in CA _________ increases with new abilities that facilitate metastasis

in carcinogensis activates what?

causes 50-60 % of cervical CA

what is liked to leukemia in snoemakers, workers in rubber cement and dyeing industries

challenge is to eradicate neoplastic cell without producing excessive toxicity and avoid damage to normal structure

in what stage of mitosis do you want chemotherapy to interrupt

directly irradiated cells can lead to genetic effects in _____ cell or ______ cells even though they retrieved to ionizing radiation exposure

UV radiation induces released of ________ in epidermis reducting immunity to skin cancer

adipose cells increase circulating levels of insulin and increases insulin like growth factor biologic activity, whats another way to saying this?

what is the most significant cause of death in malignancies

useful and definitive when neoplasm is accessible and has not spread beyond limits of surgical incision

ability to develop in particular ways related to the enviroment or setting

in carcinogenesis unmasks mutations in what

potent DNA damaging agent that causes double strand breaks