Treponema pallidum
- what does it do in terms of embranes.
crosses over thin mucous membrane or epithelial layer; cankers form
causes syphilis
Three phases to syphilis
1) canker sores
2) second form: syphilids
3) non-infectious: 3 unique lesions
1) Canker sore
3-6 wks post exposure; antibiotics--> disease clears up (you'll see)
only at primary site of inoculation
2) Syphilids
a small percentage don't get the drugs they need--> secondary form can show up 8-12 years later.
Not as infectious as primary and get lesions around the body called syphilids, which can be systemic
3) Non-infectious
----> dermatologic
three unique lesions; occurs in people who are constantly infected or do not get treatment; they are not infectious
1) dermatologic: large, shallow, nonhealing wounds (gumma= small, non cancerous growths); shallow, bleed a bit; located on tthe surfaces of long bones where there isn't much connective tissue
3) Non-infectious
----> neurosyphilis
2) neurosyphilis: small foci of necrosis in the brain--> fluid filled cysts and give person dementia (symptoms similar to Alz); because of degeneration of brain
3) Non-infectious
----> cardiosyphilis
teasing aneurysms of great vessels
all nice muscle cells and everything keeping BV intact teases away--> thin spot--> ballooning
gets so large that it works like a fist-like structure; projects in front of heart--> balloon pops under pressure--> bleed to death
Syphilis bacterium is a __. It needs to be active during the __. It can do what?
teratogen (agents that induce birth defects)
first trimester
cross barriers that others can't. Causes changes on developmental processes
Cat's eye cataract
deformed nasal bridge
Hutchinson's teeth
Disabored skin
cat's eye cataract
thick scarring of the lens--> completeyl opaque--> blind
deformed nasal bridge
nose sunken in
can also be absent
Hutchinson's teeth
knotches in teh front teeth
Sabre shin
one leg is noticeably bowed; causes one shorter leg