Spirochaetes family

• crosses over thin mucous membrane or epithelial layer; cankers form
• causes syphilis

• 1) canker sores
• 2) second form: syphilids 
• 3) non-infectious: 3 unique lesions

3-6 wks post exposure; antibiotics--> disease clears up (you'll see)

only at primary site of inoculation

• a small percentage don't get the drugs they need--> secondary form can show up 8-12 years later.
• Not as infectious as primary and get lesions around the body called syphilids, which can be systemic

• three unique lesions; occurs in people who are constantly infected or do not get treatment; they are not infectious
• 1) dermatologic: large, shallow, nonhealing wounds (gumma= small, non cancerous growths); shallow, bleed a bit; located on tthe surfaces of long bones where there isn't much connective tissue

2) neurosyphilis: small foci of necrosis in the brain--> fluid filled cysts and give person dementia (symptoms similar to Alz); because of degeneration of brain

• teasing aneurysms of great vessels
• all nice muscle cells and everything keeping BV intact teases away--> thin spot--> ballooning

gets so large that it works like a fist-like structure; projects in front of heart--> balloon pops under pressure--> bleed to death

• teratogen (agents that induce birth defects)
• first trimester
• cross barriers that others can't. Causes changes on developmental processes

• Cat's eye cataract
• deformed nasal bridge
• Hutchinson's teeth
• Disabored skin

thick scarring of the lens--> completeyl opaque--> blind

• nose sunken in
• can also be absent

knotches in teh front teeth

one leg is noticeably bowed; causes one shorter leg

• tick bite--> Lyme's disease
• lives in bacterial glands
• injects a coagulant
• classic lesion (one lesion unique and distinctive)--> Bull's eye rash (very characteristic)

premature arthritis, fatigue syndromes like chronic fatigue syndromes