Impairs iron absorption; & when combined with alcohol or simple carbs can increase uric acid.
Aluminum antacids depletes what?
phosphate and calcium
Decreases absorption of vit A,C,D, magnesium, thiamine, folacin, & iron.
Large amts of these types of foods can prolong the action of antihistamines.
- (milk, cream, almonds, alcohol)
Aspirin can cause ____ deficiency when ____ or more are taken daily.
- vitamin C
- *also causes thiamine deficiency
- & can cause iron deficiency (GI bleeding)
Absorption of calcium supplements is decreased by what?
- foods rich in oxalate (spinach, rhubarb, celery, peanuts)
- phytic acid (oatmeal, & other grain cereals)
- phosphorous (chocolate, dried beans, dried fruit, PB)
Lg amts of _______ can delay excretion of Chlorpromazine HCl. The drug can also increase ______.
- alkaline foods
- bld cholesterol
Cimetidine reduces _____ absorption.
Calcium carbonate antacids cause deficiencies of what?
Furosemide increases excretion of what?
Levodopa effectiveness is REDUCED by what?
high protein diet
Theophylline effectiveness is REDUCED by what?
high carb diet
What increases the risk of Digitalis toxicity?
Aspirin can decrease effects of?
Aspirin can INCREASE effects of?
- oral antidiabetics
- oral anticoagulants
- cortisone-like drugs
_______ can increase effects of Aspirin.
large doses of vitamin C
_______ can decrease effects of Aspirin.
_______ can decrease the effects of eye drops used for treating glaucoma.
What's the big deal about Meperidine in older adults?
Older adults have decreased renal fxn. Meperidine is excreted by kidneys = higher risk of toxicity
Avoid administering other meds within ______ of antacid.
_____ and _______ can increase INR.
Mango & Papaya
Avoid ______ with anticonvulsants (carbamazepine, lamotrigine, valproate, gabapentin, phenytoin).
grapefruit (can cause toxicity)
Verapamil can increase blood _____ level.
Decreased _____ can raise plasma levels of drugs.
______ & _______ could cause higher drug levels in plasma & might need a lower dose of med.
Dehydration & Hypoalbuminemia
Four things that decrease the metabolism of drugs and can cause toxic levels of drugs.
- liver disease
Why is the metabolism of drugs affected with older adults?
- liver size and fxn is decreased
- hapatic BF decreases by 45% b/w 25-65 yoa