Hem/Onc Pearls

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  1. What would result in the presence of spherocytes on the peripheral blood smear? What about schistocytes?
    Spherocytes are present in patients with hereditary spherocytosis or immune-mediated hemolysis.

    The presence of schistocytes suggests a microangiopathic hemolytic anemia or mechanical shearing of erythrocytes

    (Mayo Clin Proc, Vol. 84, pg. 281).
  2. Name the 4 metabolic derangements associated with the Tumor Lysis Syndrome.
    • Hyperuricemia
    • Hyperphosphatemia
    • Hyperkalemia
    • Hypocalcemia

    (Mayo Clin Proc, Vol. 81, pg. 838).
  3. What is the significance of the presence of schistocytes on a peripheral blood smear?
    • The presence of schistocytes on a peripheral blood smear would suggest a microangiopathic hemolytic anemia or mechanical shearing of erythrocytes
    • (Mayo Clin Proc, Vol. 84, pg. 281).
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Hem/Onc Pearls
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Hem/Onc Pearls
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