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Natural habitat of its causative agent such as soil or water. Cannot shed microorganisms
Reservoir
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Reservoir-like, can clinically infect and shed microorganism that cause disease
Carrier
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Can be any vertebrae, invertebrate, or inanimate object
Source
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Spread of disease following intimate contact with a carrier, or source of infection.
Contagious infection
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Ability to spread from infected to host
Transmissibility
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Transmission between members of same population
Horizontal transmission
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Transmission through generations
Vertical transmission
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Direct physical contact or close contact between host and susceptible individuals
Direct contract transmission
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Transmission involving transfer of infectious organisms from carrier to susceptible host by animate or inanimate intermediates (vehicles or fomites)
Indirect transmission
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Dependent on ability of microorganisms to travel and survive in environment for long periods of times
Airborne
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Spread by arthropods most commonly transmitted through blood
Vector borne
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Transmits infected agent without change in skin, no molts
Mechanical vector
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Transmits infected agent with molting of agent while inside vector
Biological vector
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Vector transfers organism to its offspring in ovary or placenta
Transovarial
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Transfer of etiological agent through milk
Transmammary
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Transfer from molting stages such as nymph to current host
Transstadial transmission
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Present at birth or develops in embryo or fetus in mother before or during pregnancy in uterus/placenta
Congenital transmission
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Condition, disease or disorder that can be passed on from either one or both parents to offspring
Hereditary transmission
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Microorganisms are destroyed by clinical/physical means. All life forms including spores are killed
Steralization
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Immersing objects in disinfectant solution to reduce contamination
Cold steralization
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Cleaning measure intended to prevent disease and promote health
Sanitation
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Destruction of most pathogenic microorganisms but not spores. Used on inanimate objects
Disinfection
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Disinfectives used only on skin
Antiseptic
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Suggested disease not an act of god but from living organisms
Fracastoro
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Provided glass for microscope for direct observation of bacteria
Leeuwenhoek
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Suggested specific disease is caused by a specific organism
Von Plenciz
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Discovered viruses
Iwanowski
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Distinct cause of a disease.
Etiological agent
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Single-celled animal-like
Protozoa
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Non-chlorophyll plants and divided into categories or molds and yeasts.
Fungi
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Unicellular which takes on 3 basic shapes.
Bacterial
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Intracellular parasites, at some point in life cycle must use arthropods.
Rickettsiae
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Resemble rickettsiae
Chlamydiae
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Smallest free-living organisms, no cell wall, resistant to antibiotics.
Mycoplasma (PPLO)
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PPLO
Pleuro-Pneumonia Like Organisms
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Posses DNA or RNA, no enzyme systems, have living cells
Virus
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Trauma, pressure, are examples of what?
Physical
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Toxins, poisons, heavy metals are examples of what?
Chemical
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Parasites, bacteria, viruses, are examples of what?
Infections
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Nutrition, temperature, and hygiene are examples of what?
Environmental
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Due to lack of dietary substances or inability to digest
Deficiency disease
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Includes injuries such as lacerations, fractions, gun shots
Physical trauma diseases
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Substances toxic to living tissues such as ingestion, absorption or inhalation
Poison diseases
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Involves multi-cellular organisms and unicellular organisms
Metazoan diseases
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Virulence
Dosage
Route of inoculation
Agent factors
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Immune system antibodies (immunogolbulins)
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Vaccine made from killed bacteria
Bacterin
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Other things in vaccines
- 1) Remnants of cells in which infective agent was cultured
- 2) Buffers
- 3) pH indicators
- 4) Preservatives
- 5) Adjuvants
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Added to vaccines to enhance immune response by causing inflammatory response
EX: Aluminium
Adjuvant
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B cell immunity. No memory. Consists of B lymphocytes, plasma cells, and immunoglobulins.
Humoral immunity
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T cell immnuity. No memory. T lymphocytes go to thymus to recognize unique markers on cells.
Cell mediated immunity.
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Produce inflammatory mediators which regulate chronic inflammation
Lymphocytes
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Modified lymphocytes that produce antibodies
Plasma Cells
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Failure of immune response
- 1) Maternal antibodies
- 2) Human error
- 3) Preexisting infection
- 4) Time
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Why vaccines fail
- 1) Animals response
- 2) Handling and administration of vaccine
- 3) Maternal antibody
- 4) Strain in vaccine is different from strain needed
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Hypersensitivity reaction which includes hives, facial swelling, shock, etc.
Anaphylaxis
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Lumps formed at vaccination site b/c of reaction of adjuvants
Granuloma
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In cats, grave long-term prognosis.
Sarcoma
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Vaccine antigen and corresponding antibody are deposited in walls of small blood vessels
Vasculitis
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Inflammation of sclera, iris and cornia
Uveitis
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Relationship of antibodies to antigen in ratios. 1:10 (high) 1:100 (low)
Titer
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Patient that is parasitized by etiological agent
Host
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Relationship of various factors which determine frequency and distribution of infectious diseases
Epizootiology
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TVMDL
Texas Veterinary Medical Diagnostic Laboratory
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Development of morbid conditions of a disease
Pathogenesis
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CDC
- Center for disease control
- VET: Ames, Iowa
- HUMAN: Atlanta, Georgia
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Living organism that lives at expense of another microorganism called a host
Parasite
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Signs of a disease that can be visualized with the naked eye
Symptoms
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Signs of disease deduced through tests
Clinical signs
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Inanimate object that maintains presence of etiology to pass along
Fomite
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Prevention of disease
Prophylaxis
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All diseases possible based on symptoms
Differential diagnosis
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Most likely disease based on history of whats been seen lately
Tentative diagnosis
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Absolute identification of disease based on clinical signs
Definitive diagnosis
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Death within 24 hrs
Peracute disease
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Death within 48-72 hours
Acute disease
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Mild clinical signs
Subacute disease
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No clinical signs
Subclinical disease
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Harbors the etiology but never shows symptoms or clinical signs
Chronic
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Disease transmitted to man
Zoonosis
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Attacking many animals in any region at same time
Epizootic
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Present in animal community at all times, occurring in only small numbers
Enzootic
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Chemical releases and interfers with ability of virus to cause disease by preventing replication within host cell
Interferon
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Enzymes activated during infection and binds to invading cells and produced small holes in cell wall
Complement
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4 kennel cough complexes
- Canine parainfluenza virus
- Canine adenovirus type 2
- Boredetella bronchiseptica
- Canine corona virus
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Canidae
Coyote, dingo, wolf, fox
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Mustelidae
Ferret, mink, otter, skunk, weasel, etc.
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Procyonidae
Raccoon, kinkajou, red panda
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Felidae
Lion, cheetah, jaguar, etc.
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Parvo major clinical sign
Leukopenia
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Corona clinical sign
Increased PCV
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Corona major symptom
Dehydration
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Why we use CAV-2 vaccine?
- 1) Vaccinates for kennel cough
- 2) Cross vaccinvates for CAV-1 (Hepatitis)
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Enteric bacteria
- 1) Campylobacter
- 2) Salmonella
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Parvo dates
- 1977-1978 CPV-2
- 1982 CPV-2a
- 1984 CPV-2b
- 2000 Cpv-2c
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Dehydration formula
lb/% dehydrated/500
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Maintenance formula over 20 lbs
1ml/lb/hr
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Maintenance formula under 20 lbs
2ml/lb/hr
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Parenteral immunoglobulin
IgA
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Intranasal immunoglobulin
IgG
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3 areas affected by corneal edema?
- 1) Sclera
- 2) Cornea
- 3) Iris
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with CRD watch for..?
- 1) High protein
- 2) Elevated BUN
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Bubonic meaning?
Enlarged submandibular lymph nodes
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NIH
National Institute of Health
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AVMA
American Veterinary Medical Association
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ALT
Alanine aminotransferase
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