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Acetylcholine
The chief neurotransmitter released into the synapse from the nerve's presynaptic membrane during neurotransmission.
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Acetylcholinesterase
A chemical that breaks down acetylcholine.
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Atropine
A parasympathetic blocker that decreases vagal response.
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Benzodiazepines
Medicines that help relieve nervousness, tension, and other symptoms by slowing the central nervous system.
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Defasciculating dose
A small dose of a non-depolarizing paralytic which, when administered before administering a certain drug, prevents the fasciculations associated with that drug.
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Depolarizing neuromuscular blocker
One of the two major classes of neuromuscular blockers; binds to the acetylcholine receptor and causes the muscle to depolarize or contract.
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Ketamine
A dissociative anesthetic that provides excellent amnesia, analgesia, and anesthesia during procedures and intubation. Most notably, however, it has minimal respiratory depression even at very high doses.
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Lidocaine
A common local anesthetic and antiarrhythmic drug.
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Malignant hyperthermia
A skeletal muscle disease that leads to a life-threatening reaction to succinylcholine and some other inhaled anesthetics.
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Medication-facilitated intubation
The use of adjunctive medications during intubations, either to provide sedation or cause muscular paralysis to protect patients and improve their quality of care.
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Narcotics
A class of drugs known for their ability to induce a profound state of sedation.
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Neostigmine
An acetylcholinesterase inhibitor that can be used to reverse the effects of the competitive (non-depolarizing) NMBAs.
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Neuromuscular blocking agents (NMBAs)
Medications that block transmission of nerve impulses to skeletal muscle at the neuromuscular junction.
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Non-depolarizing neuromuscular blockers
One of the two major classes of neuromuscular blockers; competes with acetylcholine for the receptor but does not cause the receptor to fire.
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Sedative
Medications used to decrease a patient's level of consciousness, lessen irritability, decrease excitability, or cause muscular relaxation.
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Succinylcholine
A depolarizing neuromuscular blocker composed of two acetylcholine molecules hooked back to back.
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Vecuronium
A non-depolarizing neuromuscular blocking agent commonly used by Paramedics in the prehospital setting.
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