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PFA-100 Pattherns for collagen/epi and collagen/ADP
a. low plt count?
b. low hematocrit?
c. vWD, plt defects, drugs?
d. aspirin
e. Clopidogrel
f. acute phase
- a. prolonged/prolonged
- b. prolonged/prolonged
- c. prolonged/prolonged (both variable)
- d. prolonged/normal
- e. normal/not sensitive
- f. may be shortened/may be shortened
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Formula for corrected retic count?
(%retic x hct) / 45
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Formula for retic proliferation index?
corrected retic count / maturation index (provided based on hct level)
- if <2 suggests decreased destruction
- >2 suggests increased destruction
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Formula for Hct?
RBC x MCV
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Formula for MCH?
Hgb/RBCÂ
units picogram
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Formula for MCHC?
Hgb/Hct
units g/dL
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A T-cell neoplasm that is not cytotoxic?
ATLL
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CD25 expression in ATLL vs. Sezary?
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Last CBC parameter to change in Fe def anemia?
MCV
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How to calculate units of cryo needed for FVIII/IX/fibrinogen replacement?
- 1. Calculate blood volume: wt x 70mL/kg
- 2. Calculate plasma volume: blood volume x (1-Hct)
- 3. Calculate factor units needed: %activity x plasma volume
- (100% for surgery, 50% for hemophilia bleeding)
- 4. Cryo has 80u of F8 and 150 mg fibrinogen
- Example:
- 80kg pt, hct 40%, activity 5% and want 50%, F9 vial has 500u per vial
[80kg(70mL)(1-0.4)(0.45)]/500u = 4 units (round up)
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Which neoplasm can make fibrinogen?
HCC/hepatoma (saw both written separately so pick which ever is there?)
can make fetal type by with decreased function
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Hematologic malignancy associated with Budd-Chiari?
PV
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CD10 in EBV+ DLBCL?
Negative
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What's a good cytochemical stain to help diagnose M6?
PAS
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Mode of transmission in May-Hegglin?
AD
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Elliptocytes are associated with what membrane protein mutation?
spectrin
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What happens to cholesterol levels in myeloproliferative neoplasms?
decrease
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B12 level in PDGFRA, PDGFRB, and FGFR1 neoplasms?
markedly increased
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Chromosomes of PDGFRA, PDGFRB and FGFR1?
- PDGFRA-4q12
- PDGFRB-5q31-33
- FGFR1-8q11
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What disease is associated with JMML? What pathway has mutations?
- Neurofibromatosis type 1
- RAS/MAPK
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What is a "remarkable" finding in JMML per WHO?
markedly increased hemoglobin F
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What mutations are found in RARS-T?
- mostly JAK2 V617F
- few MPL W515K/L
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Which hemoglobin besides S will have positive Sickledex test?
Hb C- Harlem
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