Amiodarone

Antiarrhythmic

Blocks sodium and myocardial potassium channels

• V-Fib
• Pulseless/unstable V-Tach

• Hypersensitivity
• Cardiogenic shock
• Sinus brady
• 2nd/3rd degree AV blocks(unless functional pacemaker is available)

• Hypotension
• Bradycardia
• Prolongation of the QRS and QT intervals

• Adult:
• V-Fib/Pulseless V-Tach unresponsive to CPR, defibrillation and vasopressors - 300mg IV/IO push. Initial dose may be followed one time within 3-5mins at 150mg IV/IO push

Recurrent life-threatening ventricular arrhythmias - Max comulative dose is 2.2g/24hrs administered as - 150mg IV/IO over 10mins(15mg/min). May repeat rapid infusion (150mg IV/IO) every 10mins as needed

• Peds: 
• Refractory V-Fib or Pulseless V-Tach - 5mg/kg IV/IO bolus, which may be repeated up to a total dose of 15mg/kg per 24hrs. Max single dose 300mg

Perfusing Supraventricular and Ventricular Tachycardias - Loading dose 5mg/kg IV/IO over 20-60mins with max single dose of 300mg. Can be repeated to a max of 15mg/kg/day

• Use in conjuction with dig may cause dig toxicity.
• Antiarrhythmics may cause increase in serum glucose level.
• Beta and Calcium channel blockers may potentiate brady, sinus arrest and AV heart blocks.

• Monitor pt for hypotension
• May worsen arrhythmia or precipitate new arrhythmia