1. Amiodarone Class
  2. Amiodarone Mech
    Blocks sodium and myocardial potassium channels
  3. Amiodarone Indication
    • V-Fib
    • Pulseless/unstable V-Tach
  4. Amiodarone Contra
    • Hypersensitivity
    • Cardiogenic shock
    • Sinus brady
    • 2nd/3rd degree AV blocks(unless functional pacemaker is available)
  5. Amiodarone Adverse
    • Hypotension
    • Bradycardia
    • Prolongation of the QRS and QT intervals
  6. Amiodarone Dosage
    • Adult:
    • V-Fib/Pulseless V-Tach unresponsive to CPR, defibrillation and vasopressors - 300mg IV/IO push. Initial dose may be followed one time within 3-5mins at 150mg IV/IO push

    Recurrent life-threatening ventricular arrhythmias - Max comulative dose is 2.2g/24hrs administered as - 150mg IV/IO over 10mins(15mg/min). May repeat rapid infusion (150mg IV/IO) every 10mins as needed

    • Peds: 
    • Refractory V-Fib or Pulseless V-Tach - 5mg/kg IV/IO bolus, which may be repeated up to a total dose of 15mg/kg per 24hrs. Max single dose 300mg

    Perfusing Supraventricular and Ventricular Tachycardias - Loading dose 5mg/kg IV/IO over 20-60mins with max single dose of 300mg. Can be repeated to a max of 15mg/kg/day
  7. Amiodarone drug interactions
    • Use in conjuction with dig may cause dig toxicity.
    • Antiarrhythmics may cause increase in serum glucose level.
    • Beta and Calcium channel blockers may potentiate brady, sinus arrest and AV heart blocks.
  8. Amiodarone special consideration
    • Monitor pt for hypotension
    • May worsen arrhythmia or precipitate new arrhythmia
Card Set