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Mechanism of Action
Increases uterine contractions.
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Indications
Postpartum hemorrhage after infant and placental delivery.
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Contraindications
Presence of second fetus, unfavorable fetal position, hypersensitivity.
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Adverse reactions
Hypotension, hypertension, tachycardia, arrhythmias, angina pectoris; anxiety, seizures, nausea, vomiting, uterine rupture; anaphylaxis.
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Drug interactions
Other vasopressors may potentiate hypertension.
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How supplied
10 USP units/1-mL ampule (10 U/mL) and prefilled syringe. 5 USP units/1-mL ampule (5 U/mL) and prefilled syringe.
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Dosage and Administration
IM administration: 3-10 units after delivery of placenta. IV administration: Mix 10-40 units in 1,000 mL of a nonhydrating diluent: Infused at 20-40 milliunits/min, titrated to severity of bleeding and uterine response.
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Duration of Action
- Onset: IM: 3-5 minutes; IV: immediate.
- Peak: variable.
- Duration: IM; 30-60 minutes; IV: 20 minutes after infusion discontinued.
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Special considerations
- Pregnancy safety: not applicable.
- Monitor vital signs, including fetal heart rate and uterine tone closely.
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