-
-
Mechanism of Action
Increases uterine contractions.
-
Indications
Postpartum hemorrhage after infant and placental delivery.
-
Contraindications
Presence of second fetus, unfavorable fetal position, hypersensitivity.
-
Adverse reactions
Hypotension, hypertension, tachycardia, arrhythmias, angina pectoris; anxiety, seizures, nausea, vomiting, uterine rupture; anaphylaxis.
-
Drug interactions
Other vasopressors may potentiate hypertension.
-
How supplied
10 USP units/1-mL ampule (10 U/mL) and prefilled syringe. 5 USP units/1-mL ampule (5 U/mL) and prefilled syringe.
-
Dosage and Administration
IM administration: 3-10 units after delivery of placenta. IV administration: Mix 10-40 units in 1,000 mL of a nonhydrating diluent: Infused at 20-40 milliunits/min, titrated to severity of bleeding and uterine response.
-
Duration of Action
- Onset: IM: 3-5 minutes; IV: immediate.
- Peak: variable.
- Duration: IM; 30-60 minutes; IV: 20 minutes after infusion discontinued.
-
Special considerations
- Pregnancy safety: not applicable.
- Monitor vital signs, including fetal heart rate and uterine tone closely.
|
|