The flashcards below were created by user
kyleannkelsey
on FreezingBlue Flashcards.
-
-
-
What group of patients is Transdermal buprenorphine (Butrans) a good choice for?
Elderly
-
What is the brand name for Transdermal buprenorphine?
Butrans
-
What is Transdermal buprenorphine (Butrans) indicated for?
Moderate to Severe chronic pain who will be on an opioid long term
-
How is Transdermal buprenorphine (Butrans) metabolized?
- CYP3A4
- No renal reduction needed
-
Do you need to reduce the dosese of Transdermal buprenorphine (Butrans) for renal insufficiency?
No
-
What are the benefits of Transdermal buprenorphine (Butrans)?
- No peak
- No trough
- Slower increase
- Lower SEs
-
What are the risk of Transdermal buprenorphine (Butrans) at > 20 mcg/hour?
QT prologation
-
What are the doses of Transdermal buprenorphine (Butrans)?/
5, 10 and 20 mcg/hour
-
How often is Transdermal buprenorphine (Butrans) dosed?
Weekly
-
What is Opana?
Oxymorphone
-
What is the suggested elderly dose for Opanan IR (Oxymorphone)?
5 mg Q6 hours
-
What isteh suggested elederly dose for Opana ER?
5 mg Q12 hours
-
Describe the Metabolism/excretion of Opana (Oxymorphone):
- No significant CYP450 metabolism
- Renal excretion
- Food with administration leads to high peak levels
- Dose dumping with alcohol
-
What is the dose ration fo Oxymorphone:Oxycodone?
-
Oxymorphone has a 40% higher plasma concentration in what patient population?
> 65 years
-
-
What class of drug is tramadol (ultram)?
SNRI and Opioid agonist
-
What is the max daily dose of Tramadol (Ultram)?
400 mg
-
-
What us the max daily dose of Tramadol (Ryzolt)?
300 mg
-
What are the SE for Tramadol (Ultram)?
-
What group of patients should you adjust the dose of Tramadol (Ultram) in?
-
What types of pain is Tramadol (Ultram) particularly useful in treating?
Chronic or Neuropathic pain
-
What is Nucynta?
Tapentadol
-
What is the MOA of Tapentadol (Nucynta)?
SNRI and Opioid agonist
-
What are the indications of Tapentadol (Nucynta)?
Moderate to severe pain
-
What schedule is Tapentadol (Nucynta)?
II
-
What is the dose of Tapentadol (Nucynta)?
- 50-100 mg Q4-6 hours
- Max 700 mg/day
-
What are the indications for Methadone?
- Morphine allergy
- Renal impairment
- Neuropathic pain
- Cancer pain
- Pain refractory to other agents
-
What are the precautions of Methadone pain?
- Respiratory depression
- QT-interval prolongation
-
What is the Morphine: Methadone ratio, when morphine is <100 mg/day?
- 3:1
-
- What is the Morphine: Methadone ratio, when morphine is between101-300 mg/day?
- 5:1
-
What is the Morphine: Methadone ratio, when morphine is between 301-600 mg/day?
10:1
-
What is the Morphine: Methadone ratio, when morphine is between 601-800 mg/day?
12:1
-
What is the Morphine: Methadone ratio, when morphine is between 801-1000 mg/day?
15:1
-
What is the Morphine: Methadone ratio, when morphine is between >1001 mg/day?
20:1
-
Which Opiods are metabolized by the liver to active metabolites?
Codeine and Meperidine
-
What are the CYP2D6 metabolized opioids?
- Codeine
- Oxycodone
- Hydrocodone
-
Whata rethe general Opioid SEs?
- CNS (sedation, clouding, confusion)
- GI (constipation, N/V)
- Repiratory depression
- Pruritis
|
|