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PHRD6085 Pharmacotherapy Lecture 3 - Antihypertensive Agents

The flashcards below were created by user daynuhmay on FreezingBlue Flashcards. Home Mobile Quiz receptors on vascular smooth muscle that promote contraction (3) 1) 1 2) AT1 3) ETA receptors on vascular SM that promote relaxation (2) 1) 2 2) NP nerve cell receptor that prevents NE release (leads to dilation of SM) 1) 2 2 nerve cell receptors that facilitate NE release (leads to contraction of SM) 1) AT1 2) 2 MOA of vasopeptidase inhibitors inhibit angiotensin II formation (or receptor actions) 3 examples of centrally-active sympatholytic drugs (2 R agonists) 1) clonidine 2) methyldopa 3) monoxidine advantage of monoxidine over clonidine no rebound HTN MOAs of adrenergic neuron-blocking drugs (2) 1) decrease NE release from sympathetic neurons 2) elicit partial depletion of CCAs example of adrenergic neuron blocking drug reserpine activation of 1 R in the JGA leads to... inc renin secretion -> inc AngII -> aldosterone -azosin's 1-adrenoceptor antagonists block vasoconstrictor effects of CCAs to dec PVR in aterioles & dec VR in veins most prevalent initial SE in -azosin's orthostatic HTN -olol's -adrenoceptor antagonists block cardiac effects of CCAs to dec PVR 2 major SEs of methyldopa 1) hemolytic anemia 2) hepatoxicity notable SE of reserpine mental depression (by depletion of 5HT) advantage of dihydropyridines over diltiazem/verapamil calcium channel antagonist that is selective for arterioles => won't depress the heart -ipine's calcium-channel antagonists arteriole-selective dihydropyridines MOA of hydralazine relaxes arteriolar SM by NO release & hyperpolarization of vascular SM notable SEs for hydralazine (2) SLE syndrome secondary tachyphylaxis MOA of minoxidil activates ATP-sensitive K+ channels to hyperpolarize vasc SM, inhibit VOCCs, relax arteriolar SM notable SEs of minoxidil (2) 1) fluid retention 2) hypertrichosis -pril's ACE inhibitors inhibit both AngII formation & bradykinin degradation notable SEs of -pril's (5) 1) dry cough 2) angioedema 3) teratogenic 4) acute renal failure 5) hyperkalemia -artan's AngII receptor antagonists HTN drug class removed from market due to severity of angioedema vasopeptidase inhibitors (-atrilat) -kiren's renin inhibitors block formation of AngI & AngII -sentan's endothelin R antagonists block ETA receptor notable SEs of -sentan's (5) 1) peripheral edema 2) nasal congestion 3) flushing 4) liver injury 5) pregnancy category X anti-hypertensive drug class in which compensatory fluid-retention does NOT occur calcium channel antagonists common long-term effects of all anti-hypertensive agents dec afterload (PVR/SVR)

Author daynuhmay ID 281259 Card Set PHRD6085 Pharmacotherapy Lecture 3 - Antihypertensive Agents Description Antihypertensive Agents Updated 2014-08-25T08:54:37Z Show Answers