systemic pharm nbeo4.txt

  1. What nucleotide synthesis blockers are there?
    • Sulfonamides
    • Trimethoprim
    • Pyrimethamine
  2. What sulfonamides are there?
    • Sulfusixazole
    • Sulfacetamide
    • Sulfamethoxazole
    • Sulfadiazine
  3. What are sulfonamides used for?
    • Blepharitis
    • Conjunctivitis
    • UTIs when used with trimethoprim
    • Toxoplasmosis (sulfadiazine+ pyrimethamine)
  4. What sulfonamide is used to treat toxoplasmosis?
    Sulfadiazine + pyrimethamine
  5. What are major adverse effects of sulfonamides?
    • Nephrotoxicity
    • Myopic changes
    • SJS
    • Contraindicated in preggers
  6. What is polymixin B comprised of?
    Polymixin B + trimethoprim
  7. What are major adverse effects of trimethoprim?
    • Aplastic anemia
    • Bone marrow suppression
    • Leukopenia
    • Granulocytopenia
    • SJS
  8. What is the mode of action of penicillins and cephalosporins?
    • Cell wall synthesis blockers
    • With b-lactam ring
    • Works directly on peptidoglycan through inhibition of transpeptidase
  9. What are major adverse effects of PCN and cephalosporins?
    • Acute Hypersensitivity (type 1 reactions) (15% chance)
    • Dermatitis (type 4 reaction)
    • Voided oral contraceptives effect
  10. What gram type do natural penicillins affect?
    Gram +
  11. What do natural penicillins treat?
    • Streptococcus
    • Syphilis
    • Meningitis
    • Pneumococcus
  12. What gram type do amino penicillins affect?
    Gram + and wider spectrum into gram (-)
  13. What do amino penicillins treat?
    • Otitis media
    • H. influenzae (respiratory)
  14. What amino penicillins are there?
    • Ampicillin
    • Amoxicillin
  15. What is Augmentin made out of?
    Amoxicillin + clavulanic acid
  16. What type of penicillins are not resistant to penicillinase?
    Amino penicillins
  17. What amino penicillin is a penicillinase inhibitor?
  18. What PCN is IM or IV only?
    PCN G
  19. What PCN is PO?
    PCN V
  20. What do penicillinase resistant penicillins treat?
    • Narrow spectrum
    • Staph aureus
    • Staphylococcus epidermidis
  21. What is the major adverse effect with methicillin?
    Can cause interstitial nephritis
  22. What PCN treats orbital cellulitis?
  23. What PCN is used in eyelid infections such as hordeolums and blepharitis?
  24. What are contraindications of cephalosporins?
    • Hemophilia
    • Hypersensitivy
  25. What cephalosporin is a 1st generation?
    Cephalexin (Keflex)
  26. What is cephalexin used for?
    • Skn infections
    • Dacryoadenitis
    • Dacryocystitis
    • Preseptal cellulitis
  27. What cephalosporin is a 2nd generation?
  28. What cephalosporin is a 3rd generation?
  29. What is ceftriaxone used for?
    • Meningitis
    • DOC for gonorrhea (IM)
  30. What drugs are used for TB?
    • Remember RIPE cheese
    • Rifampin
    • Isoniazid
    • Pyrazinamide
    • Ethambutol
  31. Which TB drug is the only one that can be used in isolation?
  32. What type of necrosis is found in TB?
    Caseous necrosis
  33. What type of necrosis is found in heart diseases?
  34. What drug is used to treat malaria?
  35. What drug is used to treat scabies and lice?
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systemic pharm nbeo4.txt
systemic pharm nbeo4