systemic pharm nbeo2.txt

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  1. What autocoid agonists are there?
    • Prostaglandins
    • Serotonin
    • Histamine
  2. What are prostaglandins derived from?
    Arachidonic acid
  3. What do systemic prostaglandins do?
    • Concentrate in areas of inflammation
    • Promote pain and fever
    • Inhibit gastric secretions
    • Bronchoconstriction
  4. What are prostaglandin synthesis inhibitors?
    • Aspirin
    • NSAIDS
    • Steroids
  5. What is serotonin used for
    • Treating migraine headaches
    • Prozac and Zoloft
  6. What drugs are 1st generation h1 blockers?
    • Diphenhydramine
    • Chlorpheniramine maleate
    • Phenergan
  7. What drugs are 2nd generation h1 blockers
    • Loratadine
    • Fexofenadine
    • Cetirizine
  8. What drugs are H2 blockers
    • Ranitidine
    • Cimetidine
    • Famotidine
  9. What drugs are used for bronchodilation?
    • Salmeterol
    • Advair diskus
    • Albuterol
    • Terbutaline
  10. What bronchodilating drugs are fast acting?
    • Albuterol
    • Terbutaline
  11. What is the MOA of H2 blockers?
    Block acid secretion from parietal cells
  12. What H2 blocker can cause gynecomastia and loss of libido?
  13. What proton pump inhibitors are there?
    • Omeprazole
    • Esomeprazole
  14. What is the MOA of methotrexate?
    Interferes with formation of essential cellular components
  15. What is methotrexate used for?
    • RA
    • Psoriasis
    • Leukemia
    • Lymphoma
  16. What is tamoxifen used for
    Tx of breast cancer
  17. What are adverse effects of tamoxifen?
    • Crystalline retinopathy
    • Thromboembolism
    • Hot flashes
    • Increases the risk of uterine cancer
  18. What does iodine kill?
  19. what antiviral is used against influenza A, B, and Avian flu?
  20. How do antiherpetic drugs work?
    Inhibit viral DNA synthesis by selectively acting on DNA polymerase
  21. What drugs are used to treat HSV?
    • acyclovir PO 400mg
    • valacyclovir PO
    • famciclovir
    • trifluridine
  22. What is the DOC for HSV keratitis?
  23. What drug is available for Hep C?
  24. What is the MOA of ribavirin?
    Inhibits RNA polymerase
  25. What antivirals treat CMV?
    • Canciclovir
    • Foscarnet
    • Cidofovir
  26. When is CMV found?
    It is opportunistic in AIDS retinopathy
  27. What CMV drug can be delivered as an intraocular sustained release implant?
  28. what drug is given to treat CMV when ganciclovir fails?
  29. What is the 3rd line tx for CMV
  30. What are major side effects of cidofovir?
  31. What drug is used to treat HIV?
    Zidovudine (Retrovir)
  32. What drugs are included in the HIV cocktail?
    • Saquinavir
    • Ritonavir
    • Zidovudine
  33. What antifungal is the only one for fungal keratitis?
  34. Which antifungal is the only one NOT to involve ergosterol
  35. What is the MOA of natamycin?
    Binds to ergsterol and forms pores in cell wall
  36. What antifungal drug has the narrowest spectrum?
  37. What antifungal drugs are there?
    • Natamycin
    • Griseofulvin
    • Amphotericin B
    • Nystatin
    • Keroconazole
    • Flucanozole
    • Miconazole
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systemic pharm nbeo2.txt
systemic pharm nbeo2
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