systemic pharm nbeo2.txt

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What autocoid agonists are there?
- Prostaglandins
- Serotonin
- Histamine
What are prostaglandins derived from?

Arachidonic acid
What do systemic prostaglandins do?
- Concentrate in areas of inflammation
- Promote pain and fever
- Inhibit gastric secretions
- Bronchoconstriction
What are prostaglandin synthesis inhibitors?
- Aspirin
- NSAIDS
- Steroids
What is serotonin used for
- Treating migraine headaches
- Prozac and Zoloft
What drugs are 1st generation h1 blockers?
- Diphenhydramine
- Chlorpheniramine maleate
- Phenergan
What drugs are 2nd generation h1 blockers
- Loratadine
- Fexofenadine
- Cetirizine
What drugs are H2 blockers
- Ranitidine
- Cimetidine
- Famotidine
What drugs are used for bronchodilation?
- Salmeterol
- Advair diskus
- Albuterol
- Terbutaline
What bronchodilating drugs are fast acting?
- Albuterol
- Terbutaline
What is the MOA of H2 blockers?

Block acid secretion from parietal cells
What H2 blocker can cause gynecomastia and loss of libido?

Cimetidine
What proton pump inhibitors are there?
- Omeprazole
- Esomeprazole
What is the MOA of methotrexate?

Interferes with formation of essential cellular components
What is methotrexate used for?
- RA
- Psoriasis
- Leukemia
- Lymphoma
What is tamoxifen used for

Tx of breast cancer
What are adverse effects of tamoxifen?
- Crystalline retinopathy
- Thromboembolism
- Hot flashes
- Increases the risk of uterine cancer
What does iodine kill?

spores
what antiviral is used against influenza A, B, and Avian flu?

Tamiflu
How do antiherpetic drugs work?

Inhibit viral DNA synthesis by selectively acting on DNA polymerase
What drugs are used to treat HSV?
- acyclovir PO 400mg
- valacyclovir PO
- famciclovir
- trifluridine
What is the DOC for HSV keratitis?

Trifluridine
What drug is available for Hep C?

Ribavirin
What is the MOA of ribavirin?

Inhibits RNA polymerase
What antivirals treat CMV?
- Canciclovir
- Foscarnet
- Cidofovir
When is CMV found?

It is opportunistic in AIDS retinopathy
What CMV drug can be delivered as an intraocular sustained release implant?

ganciclovir
what drug is given to treat CMV when ganciclovir fails?

Foscarnet
What is the 3rd line tx for CMV

Cidofovir
What are major side effects of cidofovir?

Uveitis
What drug is used to treat HIV?

Zidovudine (Retrovir)
What drugs are included in the HIV cocktail?
- Saquinavir
- Ritonavir
- Zidovudine
What antifungal is the only one for fungal keratitis?

Natamycin
Which antifungal is the only one NOT to involve ergosterol

Griseofulvin
What is the MOA of natamycin?

Binds to ergsterol and forms pores in cell wall
What antifungal drug has the narrowest spectrum?

Nystatin
What antifungal drugs are there?
- Natamycin
- Griseofulvin
- Amphotericin B
- Nystatin
- Keroconazole
- Flucanozole
- Miconazole

Author

cjensen20

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Card Set

systemic pharm nbeo2.txt

Description

systemic pharm nbeo2

Updated

2015-02-24T20:17:03Z

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