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Lhernandez
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Diltiazem Hydrochloride(Cardizem, Lyo-Ject) Class
Calcium channel blocker
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Diltiazem Hydrochloride(Cardizem, Lyo-Ject) MOA
- Block influx of calcium ions into cardiac muscle
- Prevents spasm of coronary arteries
- Arterial/Venous vasodilator
- Reduces preload and afterload
- Reduces mycocardial O2 demand
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Diltiazem Hydrochloride(Cardizem, Lyo-Ject) Indication
- Control of rapid ventricular rates due to A-fib/flutter and re-entry SVT
- Angina
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Diltiazem Hydrochloride(Cardizem, Lyo-Ject) Contraindications
- Hypotension
- Sick sinus syndrome
- 2nd/3rd degree AV blocks
- Cardiogenic shock
- Wide complex tach
- Poison/drug induces tach
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Diltiazem Hydrochloride(Cardizem, Lyo-Ject) Adverse
- Brady
- 2nd/3rd degree AV block
- C/P
- CHF
- Syncope
- V-Fib/Tach
- Nausea
- Vomiting
- Dizzy
- Dry mouth
- Dyspnea
- Headache
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Diltiazem Hydrochloride(Cardizem, Lyo-Ject) Dosage
- Adult:
- Initial bolus - 0.25mg/kg IV over 2mins
- Inadequate response may repeat bolus in 15mins - 0.35mg/kg IV
- Maintenance infusion 5-15mg/hr
Peds: Not recommended
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