A&P Chapter 19

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  1. Familial,
    Increased SNS activity,
    Increased sodium retaining hormones,
    low Potassium-Calcium dietary intake,
    increased renin secretion,
    deficiencies of nitric oxide and prostaglandins,
    Neurogenic sleep apnea
    are all causes of what type of hypertension? What % of total is this?
    Primary or Essential Hypertension. 95% of all cases.
  2. What is the fundamental cause of primary hypertension?
    salt and water retention is the final common pathway shared
  3. Renovascular (renal artery stenosis),
    Renal parenchymal disease/chronic renal diseases (pyelonephritis or glomerulonephritis),
    hyperaldosteronism (Conn syndrome)
    Aortic Coarctation
    hyperadrenocorticism (Cushing Syndrome)
    Pregnancy induced HTN
    Exogenous substances
    are all what types of causes of HTN?
    Secondary or demonstrable causes
  4. What 3 things are responsible for short term control of BP?
    • 1) SNS
    • 2) total peripheral vascular resistance
    • 3) cardiac pumping ability
  5. What is responsible for long term control of BP?
    balancing fluid intake and output
  6. Describe the renal urinary output curve/renal function curve
    as BP increases, UOP increases (diuresis and natriuresis
  7. Describe the Renal Output Curve and Na/H2O intake
    • 2 curves:
    •      1) Renal output of H2O and salt in response to rising BP
    •      2) Net intake of Na and H2O

    Over time, intake must equal output. Where the curves intersect is the "equilibrium point" (H2O and salt intake is at 1x normal, BP is at 100 mmHg)
  8. Describe the Infinite Feedback Gain Principle
    As BP increases, UOP increases to more than intake, I/O is negative until BP normalizes and equilibrium point is reached again. The opposite is true for a decreased BP.
  9. What 2 ways can you change the equilibrium point of the renal function curve/intake curve?
    • 1) shift arterial pressure level for the renal output curve to a different pressure
    • 2) move the level of water/salt intake line
  10. How would you shift the equilibrium point to the left on the renal function curve?
    restrict sodium and water intake
  11. What two things determine arterial pressure?
    CO and TPR
  12. If renal function is normal, how long will it take to return BP back to normal? When would this not happen?
    1 day - if renal vascular resistance is increased
  13. If kidneys are functioning, will a change in TPR increase the long-term arterial pressure?

    The renal function curve must be altered. This is only done if you have an increase in renal vascular resistance.
  14. What 2 ways does increased fluid volume increase BP?
    • 1) directly by increasing CO
    • 2) indirectly by autoregulation of the arterioles in response to increased CO (increases TPR)
  15. What happens when sodium intake increases?
    • ECF osmolality increases -->
    • stimulation of thirst center and release of ADH-->
    • increased ECFV
  16. What happens in the first stage of volume loading hypertension?
    • CO, blood volume, ECFV, and BP all increase
    • TPR decreases
  17. What causes the decrease in TPR during the first stage of volume loading htn?
    baroreceptor reflex
  18. What is responsible for the increased BP in the first stage of volume loading hypertension?
    increased CO
  19. What happens in the second stage of volume loading hypertension?
    htn persists, CO returns to near normal, TPR increases
  20. What is responsible for the increased TPR during the second stage of volume loading hypertension?
    The autoregulation of the arterioles have caused them to constrict to control flow --> increased TPR
  21. Where is reining synthesized, stored, and released?
    juxtaglomerular cells in the afferent arterioles of the kidney
  22. Is renin a vasoactive substance?
  23. What triggers the release of renin?
    low arterial pressure
  24. How does renin increase blood pressure?
    • Renin -->
    • angiotensin I -->
    • angiotensin II (via ACE in pulm circ) -->
    • vasoconstriction and renal retention of salt and water
  25. What deactivates angiotensin II?
  26. What is responsible for the immediate increased in BP d/t RAAS system?
    • angiotensin is a rapid vasoconstrictor -->
    • 1) contraction of arterioles (more then veins) = increased TPR &
    • 2) venous contraction --> increased venous return to heart (increases CO)
  27. What is responsible for the long term raise in BP d/t RAAS system?
    increased fluid volume = increased BP d/t sodium and water retention
  28. What are the 2 major mechanisms by which the kidneys cause sodium and water retention in response to angiotensin?
    • 1) direct renal effects
    •      - renal arteriole constriction (less flow, less UOP)
    •      - increased reabsorption of Na and H2O
    • 2) aldosterone secretion
    •      - Na reabsorption, water follows
  29. What is the relationship between sodium intake and renin release?
    As Na intake rises, renin release will near zero
  30. How does angiotensin II affect BP?
    increases via vasocontriction
  31. How does aldosterone affect BP?
    increases via Na retention and water follows
  32. How does SNS activity affect BP?
    increases via contraction of renal vasculature --> increased reabsorption of Na/H2O and vasoconstriction
  33. How does endothelin affect BP?
    increase via vasoconstriction
  34. How does atrial natriuretic peptide affect BP?
    decreases via decreased reabsorption of Na/H2O
  35. How does Nitric Oxide affect BP?
    decrease via vasodilation
  36. How does Dopamine affect the renal vessels?
    at low doses it stimulates dopamine 1 receptors which stimulates natriuresis
  37. What are the 3 rapid response mechanisms (seconds to minutes) to control BP?
    • 1) Baroreceptor feedback
    • 2) CNS inschemic mechanism
    • 3) Chemoreceptor mechanism
  38. What are the 3 intermediate response mechanisms (minutes to hours) to control BP?
    • 1) Renin-angiotensin vasoconstriction
    • 2) stress-relaxation mechanism (increased BP = increased wall stretch = relaxation)
    • 3) capillary fluid shift mechanism
  39. What are the 2 long term mechanisms to control BP?
    • 1) Renal-blood volume pressure mechanism
    • 2) renin-angiotensin-aldosterone mechanisms
Card Set
A&P Chapter 19
The Integrated System for Pressure Control
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