Membrane Proteins

Type 1
- 1 membrane spanning helix
- C-terminus Inside cell
Type 2
- Single spanning helix
- NH₃on inside of cell
Type 3

Multiple transmembrane helicies, 1 polypeptide chain
Type 4
- Several transmembrane domains
- Different polypeptides
Type 5

Lipid linked polypeptide chain
Type 6

Transmembrane helix(ces) and a lipid linked section
Flippase

Moves a phospholipid from the outer leaflet to the cytosolic leaflet.
Floppase

Moves a phospholipid from the cytosolic leaflet to the outer leaflet.
Scramblase

Moves lipids in either direction toward equilibrium.
Simple Diffusion
- Non polar molecules only
- move down concentration gradient
Facilitated Diffusion

Down Electrochemical Gradient through a channel
Primary Active Transport

Movement against electrochemical gradient through a channel using ATP.
Secondary Active Transport

Move against electrochemical gradient driven by ion moving down its gradient
Ion channel
- Movement down elecrochemical gradient.
- May be gated by ligand or ion.
GLUT 1
- All tissues
- Glucose Uptake
GLUT 2
- Liver=removal of excess glucose from blood
- pancrease= regulation of insulin release
- intestine
GLUT3

Glucose uptake in the brain
Glut 4
- Muscle,Fat,Heart
- Activity increased by insulin

Author

lrsimmons

2762

Card Set

Membrane Proteins

Description

Types of Integral Membrane Proteins and transport

Updated

2009-12-10T23:18:17Z

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