Antipsychotic Drugs

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  1. Common symptoms of psychotic disorders
    • disturbances of reality and perception
    • impaired cognitive functions
    • mood disturbances
  2. Age of onset of Scizophrenia
  3. symptoms of schizophrenia
    • impaired rational thinking
    • management of emotions
    • decision making
    • social relations
  4. what is a delusion?
    a belief not supported by science of culture
  5. Positive symptoms of schizophrenia
    • delusions
    • hallucinations
    • reality distortions (illusions)
  6. Negative symptoms of Schizophrenia
    • emotional unresponsiveness
    • emotional and social withdrawal
  7. Causes of Schizophrenia
    • No known cause
    • genetic factors might contribute
    • developmental factors
    • environmental factors
  8. main drug used for Schizophrenia
  9. Two types of antipsychotic drugs
    typical and atypical
  10. Purpose of typical antipsychotics
    • alleviate positive symptoms
    • binds to 70-80% of D2 dopamine receptors
  11. Purpose of atypical antipsychotics
    • block less receptors (40-60%)
    • alleviate both positive and negative symptoms
    • Also block 70-90% 5-HT2A serotonin receptors
  12. (General) Side effects of typical antipsychotic drugs
    • salivate, lacrimate (tears), urinate, deficate, perspirate
    • makes you move funny
  13. which is more expensive? Typical or Atypical
  14. Which type of drug makes you fat and have high cholesterol?
  15. What are the major side effect of clozapine?
    seizures and agranulocytosis , moderate to severe weight gain
  16. What is a major side effect of risperidone
  17. What is the mesolimbic function of dopamine?
    emotions , reward
  18. What is the nigrostriatal function of dopamine?
  19. Tuberoinfundibular function of dopamine?
    endocrine control
  20. What does haloperidol do?
    • blocks postsynaptic dopamine D2 receptors
    • and mainly alleviates positive symptoms
  21. What is an extrapyramidal symptom?
    side effects such as akinesia (inability to initiate movement) and akathisia (inability to remain motionless)
  22. What is tardive Dyskinesia?
    involuntary movements of face and extremities
  23. adverse effects of haloperidol?
    extrapyramidal symptoms similar to parkinsons disease and neuroleptic malignant syndrome
  24. How to treat neuroleptic malignant syndrome caused by haloperidol
    Immediate medial intervention of bromocryptine( DA agonist) and dantrolene (muscle relaxant)
  25. when do you use Clozapine?
    when the other drugs don't work (1/3 of people start to get better)
  26. Why is clozapine not used as first line drug?
    the bad side effects of agranlocytosis (you have to go in for blood tests every week for 6 weeks)
  27. why is clozapine a "dirty drug"?
    because it binds to over a dozen receptors and other targets
  28. How many people with recover from a acute psychotic episode and require no further drug therapy?
    only a small minority
  29. What percent of schizo attempt suicide?
    • 20%
    • 10% succeed
Card Set
Antipsychotic Drugs
Schizophrenia and other diseases
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