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  1. Atopy
    Predisposition to become IgE-sensitized
  2. Conditions associated with atopy
    asthma, atopic dermatitis, psoriasis, autoimmune disease
  3. hygiene hypothesis
    lack of early childhood exposure to infectious agents, symbiotic microorganisms and parasites increases susceptibility to allergic diseases
  4. Hygiene hypothesis - development
    why hay fever and eczema less common in children in large families

    why allergies more common in developed societies
  5. Helminthic Therapy
    Inoculation of patient with specific parasitic intestinal nematode (helminth)
  6. IL-4, IL-13
    Stimulates and amplifies Th2-cell response
  7. IL-3, IL-5, GM-CSF
    Promote eosinophil production and activation
  8. TNF-α
    • Pro - Inflammatory
    • Stimulates cytokine production
  9. Histamine effects 1
    Dilates post capillary venules (site of extravasation of blood cells)

    Increase blood flow and vessel permeability
  10. Histamine effects 2
    Activates endothelium

    Produces inflammation

    Intestinal/smooth muscle contraction

    Increased mucus secretion

    Enhance Th1 proliferation
  11. Secondary Mediators
    more prolonged and pronounced effects,


  12. leukotrienes
    mediate bronchoconstriction

    increase vascular permeability

    increase mucus production
  13. Prostaglandins
    induce vasodilation

    induce bronchoconstriction

    induce platelet aggregation
  14. Type I Hypersensitivity
    IgE mediated
  15. Type II Hypersensitivity
    IgG mediated

    Cell associated antigen
  16. Examples of Type II Hypersensitivity
    • Hemolytic Anemia
    • (1) Transfusion Reactions
    • (2) Hemolytic Disease of the Newborn
    • (3) Drug induced hemolytic anemia
  17. HDN (Hemolytic Disease of the Newborn)
    Erythroblastosis Fatalis
    • Mother = Rh -
    • 1st Baby = Rh+ -> induces Anti-Rh IgM production in the mother

    2nd Baby = Rh+, memory cells attack fetal blood cells resulting in anemia in baby
Card Set
Type I Hypersensitivity
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