-
valproate/valproic acid
- Depakene, Stavzor, Depacon
- mood stabilizer: T type calcium channel blocker and fast sodium channel blocker - increases GABA activity (inhibitory NT)
- BBW (3): hepatic failure, teratogenicity, pancreatitis
-
divalproex
- Depakote, Depakote ER, Depakote Sprinkle
- Depakote = delayed release
- mood stabilizer: T type calcium channel blocker and fast sodium channel blocker - increases GABA activity (inhibitory NT)
- BBW (3): hepatic failure, teratogenicity, pancreatitis
-
lamotrigine
- Lamictal, Lamictal ODT, Lamictal CD, Lamictal XR
- mood stabilizer: inhibits release of glutamate and aspartate (excitatory AA), fast sodium channel blocker and T type calcium channel blocker stabilizing neuronal membranes
- NOT used in mania
-
lithium
- Lithobid
- mood stabilizer: influencing reuptake of serotonin and norepi and inhibiting postsynaptic D2 receptor supersensitivity
- monitor toxicity
-
aripiprazole
- Abilify, Abilify Discmelt
- SGA
- FDA approved: manic, mixed symptoms, maintenance, +/- lithium or valproate
-
olanzapine + fluoxetine
- Symbyax
- SGA + antidepressant
- FDA approved: bipolar depression, 2nd line option due to metabolic effects from olanzapine
-
olanzapine
- Zyprexa, Zydis ODT, Relprevv inj
- SGA
- FDA approved: manic, mixed episodes +/- lithium or valproate, or monotherapy maintenance
-
quetiapine
- Seroquel, Seroquel XR
- SGA
- FDA approved: mania/maintenance with lithium or divalproex, bipolar depression
-
risperidone
- Risperdal
- SGA
- FDA approved: monotherapy, with lithium or valproate for acute mania or mixed episodes
-
ziprasidone
- Geodone
- SGA
- FDA approved: with lithium or valproate for maintenance, or alone with manic/mixed episodes
-
asenapine
- Saphris
- SGA
- FDA approved: acute manic or mixed episodes, +/- lithium or valproate
-
lurasidone
- Latuda
- SGA
- FDA approved: bipolar depression, +/- lithium or valproate
|
|
