1. Class
    Calcium channel blocker
  2. Mechanism of action
    Inhibits movement of calcium ions across cell membranes; calcium channel blocker, arterial and venous vasdilator; reduce preload and afterload; prevents coronary artery spasm and decreases total peripheral resistance; reduces myocardial oxygen demand; does not prolong AV nodal conduction.
  3. Indications
    Hypertensive crisis, angina pectoris, pulmonary edema (investigational)
  4. Contraindications
    Compensatory hypertension, hypotension, hypersensitivity.
  5. Adverse reactions
    Hypotension, CHF, headche, dizzness, lightheadedness, facial flushing, heat sensation, weakness, nausea, muscle cramps, mood changes, peripheral edema myocardial infarction.
  6. Drug interactions
    Beta blockers may potentiate effects. Effects of theophyllinemay be increased. Antihypertensives may potentiate hypotensive effects.
  7. How supplied
    Soft gelatin capsules, 10-20 mg. Extended-release tablets, 30, 60, 90 mg
  8. Dosage and administration
    Adult: 10mg SL or buccal (puncture end of capsule with needle and squeeze; may administer SL or buccally or may have patient bite and swallow); may repeat in 30 minutes. Pediatric: Not recommended
  9. Duration of action
    Onset: 15-30 minutes. Peak effect: 1-3 hours. Durations: 6-8 hours.
  10. Special considerations
    Pregnancy safety: Catergory C. Does not slow AV nodal activity. Have beta blocker available for control of reflex tachcardia. Use with caution in geriatric population; hypotension and angina pectoris may occur.
Card Set
Paramedic#2 Drugs