-
fluoxetine
- Prozac, Sarafem, Prozac Weekly
- SSRI
- sexual side effects
- longest half life - 5 week washout
-
fluoxetine + olanzapine
- Symbyax
- SSRI + atypical antipsychotic - resistant depression (QHS)
-
paroxetine
- Paxil, Pexeva, Paxil CR, Brisdelle (x)
- SSRI
-
-
sertraline
- Zoloft
- SSRI
- top choice for cardiac patients
-
citalopram
- Celexa
- SSRI
- QT risk >40 mg/day or >20 mg/day if 60+ years, liver dx, 2C19 issues
- not in children, avoid if cardiac risk
-
escitalopram
- Lexapro (s form)
- SSRI
- QT risk >20 mg/day, do not exceed 10 mg/day in elderly
-
vilazodone
- Viibryd
- SSRI + 5HT1A partial agonist
- With Food, Less sexual SEs
-
vortioxetine
- Brintellex
- SSRI + 5HT3, 5HT7, receptor antagonist, 5HT1A agonist, partial 5HT1B agonist
-
venlafaxine
- Effexor, Effexor XR
- SNRI - Depression, GAD
- increase BP
-
duloxetine
- Cymbalta
- SNRI - Depression, peripheral neuropathy (pain), fibromyalgia, GAD, chronic low back pain, chronic osteoarthritis painincrease BP
-
desvenlafaxine
- Pristiq
- SNRI - Depression
- increase BP
-
levomilnacipran
- Fetzima
- SNRI - Depression
- increase BP
-
amitriptyline
- Elavil
- tricyclic - NE, 5HT reuptake inhibitors; ACh, histamine blockers
- tertiary amine
-
doxepin
- Zonalon (pruritis), Silenor (insomnia)
- tricyclic - NE, 5HT reuptake inhibitors; ACh, histamine blockers
- tertiary amine
-
clomipramine
- Anafranil
- tricyclic - NE, 5HT reuptake inhibitors; ACh, histamine blockers
- tertiary amine
-
imipramine
- Tofranil, Trofranil PM (not interchangeable)
- tricyclic - NE, 5HT reuptake inhibitors; ACh, histamine blockers
- tertiary amine
-
trimipramine
- Surmontil
- tricyclic - NE, 5HT reuptake inhibitors; ACh, histamine blockers
- tertiary amine
-
amoxapine
- -
- tricyclic - NE, 5HT reuptake inhibitors; ACh, histamine blockers
- secondary amine
-
desipramine
- Norpramine
- tricyclic - NE, 5HT reuptake inhibitors; ACh, histamine blockers
- secondary amine
-
Maprotiline
- -
- tricyclic - NE, 5HT reuptake inhibitors; ACh, histamine blockers
- secondary amine
-
Nortriptyline
- Pamelor
- tricyclic - NE, 5HT reuptake inhibitors; ACh, histamine blockers
- secondary amine
-
protriptyline
- Vivactil
- tricyclic - NE, 5HT reuptake inhibitors; ACh, histamine blockers
- secondary amine
-
-
-
-
selegiline transdermal patch
- Ensam
- MAOI B selective inhibitor
-
bupropion
- Aplenzin, Budeprion SR, Budeprion XL, Wellbutrin SR, Wellbutrin XL, Wellbutrin, Forfivo XL
- DA and NE reuptake inhibitor
-
mirtazapine
- Remeron, Remeron SolTab
- inhibits 5HT reuptake; alpha1-adrenergic and histamine blocker
- sedation, increase appetite, weight gain
-
aripiprazole
- Abilify, Abilify Discmelt
- antipsychotic - treatment resistance depression only
-
olanzapine + fluoxetine
- Symbyax
- antipsychotic - treatment resistance depression only
-
quetiapine extended-release
- Seroquel, Seroquel XR
- antipsychotic - treatment resistance depression only
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