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Depolarizing neuromuscular blocker; ultra-short acting; binds to nicotinicM receptors (and initially activates them); used to ↑ muscle relaxation (flaccid paralysis) during short procedures (e.g. endotracheal intubation, endoscopy)
succinylcholine [Anectine]
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Side effects of succinylcholine
Malignant hyperthermia; post-op muscle pain; no CNS effects (i.e. does not diminish consciousness or perception of pain)
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Beta1 & Beta2 adrenergic receptor antagonist (competitive) used to treat HTN, angina pectoris, dysrhythmias, MI
propanolol [Inderal]
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Side effects of propanolol
brachycardia => heart failure; bronchoconstriction; _|_ of glycogenolysis; CNS effects
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Alpha1 Adrenergic receptor antagonist (competitive) used to treat HTN, also for benign prostatic hyperplasia (relaxes muscles in bladder)
prazosin [Minipress]
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Side effects of prazosin [Minipress]
Orthostatic hypotension; reflex tachycardia; nasal congestion
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Muscarinic receptor agonist used in treatment of urinary retention (e.g. post-op & postpartum)
bethanechol [Urecholine]
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Side effects of bethanechol [Urecholine]
- ↑ sweating, gastric acid secretion, GI motility vasodilation, miosis/poor vision
- decreased HR
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Competitive (non-depolarizing) neuromuscular blocker; _|_ nicotinicM receptors, used to cause muscle relaxation (flaccid paralysis) during surgery, intubation, mechanical ventilation
tubocurarine
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Side effects of tubocurarine
Respiratory depression/arrest; decrease in BP, HR; no CNS effect (i.e. does not diminish consciousness or perception of pain)
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Cholinesterase inhibitor for treatment of myasthenia gravis or to reverse effects of tubocurarine
neostigmine [Prostigmine]
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Side effects of neostigmine [Prostigmine]
Excessive mAchR activation, excessive ACh accumulation in NMJ => paralysis (e.g. of respiratory muscles)
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Muscarinic drugs act primarily on which locations
Heart, sweat/salivary glands, acid secreting cells of stomach, smooth muscles, eyes
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This drug can be used to treat muscarinic poisoning (e.g. bethanechol, neostigmine, poison mushrooms)
atropine [Sal-tropine]
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This drug can be used to reverse effects of non-depolarizing neuromuscular blockers (e.g. tubocurarine)
neostigmine (a cholinesterase inhibitor - increases available Ach at NMJ to compete with tubocurarine)
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