PHARM 3 Cardiac

  1. Mech of axn of Adrenergic blockers. Example?
    • decrease cardiac workload by slowing HR (B1) and 
    • decreasing BP (a1)
    • example = carvedilol
  2. Hydralazine acts on ______ to decrease PV resistance, reduce afterload, increase CO.
  3. Mech of axn of cardiac glycosides. Example?
    • increase C.O. by increasing force of contraction
    • example = digoxin
  4. What type of drug is digoxin?
    cardiac glycoside
  5. Mech of axn of Phosphodiesterase inhibitors. Example?
    • increase CO by increasing force of contraction
    • example = milirinone
  6. How do vasodilators work? Example?
    • DECREASE cardiac workload by dilating BV & reducing preload
    • example = isosorbide dinitrate with hydrazine
  7. How do ACEI and ARBS work? Example?
    • Increase CO by lowering arterial BP (afterload) and BV, dilates veins
    • (ACEIs block aldosterone which increases BV & preload)
    • example = lisinopril
  8. How do diuretics work? Example?
    • Increase CO by reducing FV and BP
    • example = furosemide (Lasix)
  9. Drug of choice for HF.
  10. Drug that is effective in preventing HF following an MI.
  11. Adverse effects of ACEIs.
    • Angioedema
    • Hyperkalemia
    • Dry hacking cough
  12. "prils"
  13. ACEI cause K+  ______ and loop diuretics cause K+ _______.
    • retention
    • excretion
  14. ARBS & ACEIs may cause symptomatic _______.
  15. What type of drug is a thiazide? Example?
    • diuretic
    • HCTZ, HydroDIURIL
  16. Side effects of diuretics.
    • Na+, K+, & H20 loss
    • hyperglycemia
    • NVD, dizziness
  17. _______ can produce a reverse remodeling of the heart, which means?
    • BB
    • decreased dilation & hypertrophy (good for treating HF after MI)
  18. Carvedilol (Coreg) & metoprolol (Toprol) are approved for _____ (outpatient). When should you hold them?
    • HF
    • BP<90, HR<60
  19. Metoprolol decreases _____ and results in ________.
    • HR
    • myocardial O2 demand
  20. What do you monitor for in a pt taking metoprolol or carvedilol?
  21. When is metoprolol contraindicated?
    Pts with 2nd or 3rd degree AV block WITHOUT a pacemaker
  22. Use caution with BB in patients with?
    • diabetes (masks signs of hypoglycemia),
    • PVD,
    • hepatic impairment
  23. What is carvedilol used for? Contraindicated?
    • to treat HF  (adrenergic blocker)
    • pts with 2nd or 3rd degree heart block without pacemaker
  24. Isosorbide works on _____ and reduces _____ by directly dilating them.
    • veins
    • preload
  25. Adverse effect of hydralazine.
    orthostatic hypotension (dilation of arterioles)
  26. Adverse effect of isosorbide.
    peripheral edema (dilation of veins)
  27. Metoprolol decreases HR and results in _____, where Carvedilol decreases HR, _____ and _______ and causes ______.
    • reduced myocardial O2 consumption
    • afterload, contractility (B1 receptors), vasodilation
  28. NESIRITIDE is identical to what?
    human beta-type natriuretic peptide
  29. In therapeutic doses, nesiritide (Natrecor) causes _____.
    vasodilaction, reducing preload.
  30. Nesiritide (Natrecor) is administered _____.
    • IV with continuous monitoring
    • (risk for severe hypotension)
  31. What is nesiritide (Natrecor) indicated for?
    ACUTELY decompensated HF
  32. What is extremely important to monitor in a pt receiving nesiritide (Natrecor)?
    • Monitor BP every 10-15 min due to risk of severe hypotension (usually first 15-60 min of infusion).
    • Can cut off drug if needed (very short half-life)
  33. How is digoxin administered?
    IV or PO only - never IM or SubQ
  34. How are dobutamine & dopamine administered?
    IV infusion
  35. Mech of axn for digoxin.
    • inhibits Na+ K+ pump
    • increases intracellular Ca++
    • increases contractility & force
    • decreases AV conduction velocity
  36. Do not administer digoxin with a HR below?
  37. What is important to do prior to administering digoxin?
    Take apical pulse for one FULL minute
  38. Digoxin must be given over a minimum of _______.
    FIVE minutes (can dilute 4-5mL)
  39. Digoxin is highly protein bound. What does this mean?
    Low albumin would mean more free digoxin
  40. 1/2 life of digoxin.
    36-48 hrs
  41. Adverse effects of digoxin.
    • ventricular dysrhythmias including sudden cardiac death
    • *most common cause is diuretic K+ depletion*
  42. Normal serum digoxin levels & when they are drawn.
    • .5 - 1.5 mg/mL
    • 6-12 hrs after last dose
  43. Earliest sign of digoxin toxicity.
  44. Digoxin toxicity is often unrecognized & may present with the same manifestations as what?
    the flu
  45. Why is digoxin contraindicated in a pt with MI?
    it increases O2 demand & squeeze
  46. How does digoxin interact with diuretics?
    diuretics can cause hypokalemia, which makes the heart more sensitive to digoxin and pt can exhibit toxicity at "normal" serum levels of digoxin
  47. Digoxin reversal agent.
    digoxin immune Fab (Digibind)
  48. Teaching points with Digoxin.
    • Take same time each day
    • Don't skip or double dose
    • Do not switch brands
    • Do not breast feed
  49. Two most common AEs with Beta-adrenergic agonists.
    • tachycardia
    • dysrhythmias
  50. Sympathomimetic (beta agonists) IV drug of choice and why.
    • Dobutamine (Dobutrex) 
    • causes minimal changes to HR or BP
  51. Dopamine is used in patients with _____ and particularly _______.
    • HF
    • hypotension
  52. A low _____ level increases the risk of digoxin toxicity.
  53. The primary problem associated with HF is _______, therefore ______ is the drug of choice. (#8, 187, Rationales)
    • decreased contractility
    • digoxin
    • (positive inotrope
  54. ________ is used for sinus bradycardia. (#8, p.187, Rationales)
  55. Propolanol is a _______ and is used for ______ and _______. (#8, p.187, Rationales)
    • beta-blocker
    • hypertension & angina
  56. Verapamil is a ________ and is used for what? (#8, p.187, Rationales)
    • CCB
    • hyptertension
    • tachycardia
    • angina
    • (negative inotrope)
  57. CCB can cause ______ if taken in excessive doses. (#8, p.187, Rationales)
Card Set
PHARM 3 Cardiac
Pharm 3