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mucosa in small intestine has
absorptive cells, goblet cells, glands, paneth cells, and enteroendocrine cells
-
-
doudenal glands of Bruner
in mucosa, secrete alkaline mucus. only exist in doudenum
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serosa in small intestine has
circular folds, ridges (cause chyme to spiral and increase surface area)
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villi
finger-like projections that contain arterioles, venules, capillaries, lacteals
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microvilli
projections from cells, something about enzymes
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Peyer's patch
only in ileum, produce intestinal juices
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brush border
secretes enzymes, most digestion due to these enzymes
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mechanical digestion governed by
myenteric plexus
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chemical digestion
carbs, by pancreatic amylase, proteins, lipids, nucleic acids
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large intestine functions
absorb water, expel feces
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parts of large intestine
cecum, appendix, ascending colon, transverse colon, descending colon, sigmoid colon, ileocecal sphincter, internal and external anal sphincter
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mucosa of large intestine
absorptive and has goblet cells
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muscularis of large intestine
longitudinal muscle modified to form teniae coli
-
-
chemical digestion in large intestine
bacteria derment carbs, produce some b & K vitamins
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pancreas
produces digestive juice for small intestine
-
pancreatic juice
enters in duodeum at hepatopancreatic ampulla, contolled by sphincter of oddi
-
majority of cells in pancreas
acini, exocrine
-
12% of pancreatic cells are
islets of langerhans, endocrine, secrete hormones glucagon, insulin, somatostatin, and pancreatic polypeptide
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pancreatic juice
water, sodium bicarbonate, enzymes, pancreatic amylase, proteolytic enzymes, pnacreatic lipase, ribonuclease, and deoxyribosenuclease
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liver
largest and heaviest gland
-
hepatocytes
secrete bile that emulsifies fat
-
bile canaliculi
spaces between hepatocytes that transport bile onto small bile ducts in portal canal
-
hepatic sinusoids
highly permeable blood capillaries receiving oxygenated blood from hepatic artery and deoxygenated blood rich in nutrients from hepatic portal vein
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kupffer cells
macrophages that eat dead RBCs
-
functions of liver
bile production, lipid metabolism, cholesterol and lipoprotein metabolism, plasma protein synthesis, vitamin storage, degradtion of hormones, detoxification of drugs and toxins, filtration of blood
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portal triad
central vein, hepatic sinusoids
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hepatic portal vein formed by
gastric veins, splenic veins, pancreatic veins, superior mesenteric vein, inferior mesenteric vein
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bile
about 1L secreted a day
-
bilirubin
derived from hemaglobin, elevated amounts cause jaundice
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hepatitis
inflammation of liver, caused by hepatitis A, B, and C.Can lead to liver damamge and cancer
-
cirrhosis
liver becomes fatty and eventually replaced by fibrous scar tissue. alcoholics, obese are at risk. can lead to liver failure, where liver cannot regenerate fast enough
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gallbladder
stores and concentrates bile, smooth muscle, absorbs water and ions
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gastrin
hormone that regulates hormone production
-
cholecystokin
allows bile to enter duodenum
-
secretin
stimulates secretion of enzymes and buffers from pancreas
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kidney function
regulate blood pH, volume, pressure, osmolarity, glucose level, hormones renin and erythropoetin, and excretion of waste.
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retroperitoneal
kidneys are this: outside of pelvic cavity
-
minor calyx
tip of renal pyramid
-
urine making
cortex->medulla->cortex->down tubule->into pelvis->out ureter
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renal sinus
space around renal pelvis
-
blood supply to kidney
L & R renal arteries
-
branches of L & R renal arteries
segmented->interlobar->arcuate->interlobular->afferent arterioles
-
each nephron has one
afferent arteriole
-
glomerulus formed by
afferent arterioles, which reunite to form efferent arteriole
-
_____ nerves regulate blood flow
vasomotor
-
3 urine processes
- glomerule filtration
- tubular re absorption
- tubular secretion
-
renin
hormone that eventually controls blood pressure
-
nephron
- microscopic functional unit
- loop of henle
-
renal corpuscle
- filters blood plasma, found in cortex
- contains glomerular capsule
-
cortical nephrons
- majority of nephrons
- short loops of henle
- extend into outer region of medulla
-
juxtamedullar nephron
stimulate renin hormone production
-
layers of renal corpuscle
- visceral layer: has podocytes
- parietal layer
- mesangia cells
- bowman's capsule
-
bowman's capsule
space where urine first appears
-
macula densa
- in between afferent and efferent arterioles
- epithelial cells
- part of ascending loop of henle
-
glomerular filtrate
- fluid that enters capsular space
- 99% returned to blood plasma
-
filtration membrane
- permits filtration of water and small solutes
- prevents proteins, blood cells and platelets from crossing
-
3 barriers
- 1. glomerular fenestrations
- 2. fusal basal lamina of endothelium and podocytes
- 3. pedicels of podocytes create filtration slits with slit diaphragms
-
Net Filtration Pressure=
glomerular blood hydrostatic pressure - capsular hydrostatic pressure - blood colloid osmotic presssure
-
glomerular filtration rate
amount of filtrate formed each minute
-
proximal convoluted tubule
- cells have microvilli that create brush border
- largest amount of water and solute re absorption
-
distal convoluted tubule
major site where parathyroid hormone stimulates re absorption of Ca+
-
principal cells
- in collection ducts
- receptors for antidiruretic hormone and aldosterone
- reabsorb Na+, secrete K+
-
intercalated cells
- in collection ducts
- role in blood pH
- reabsorb K+ and HCO3- and secrete H+
-
-
-
when blood ____ or ____ decreases, _____ is decreased in afferent ______ of ______, stimulates ______ cells to secrete ______
pressure, volume, pressure, arterioles, glomerulus, juxtamedullar, renin
-
renin work
- renin-->angiotensinogen (plasma protein)
- ----------V-------------
- angiotensin I <-- angiotensis converting enzyme
- ----------V------------------
- angiotensin II
-
angiotensin II
- vasoconstrict afferent arterioles: decrease filtration
- sitmulates production of aldosterone: enhances reabsorption of Na+ and Cl-
-
atrial natriuetic peptide
- prevents reabsorption of water
- suppresses secretion of ADH
-
diabetes insipidis
no ADH
-
counter current exchange
movement of water and solutes between loop of henle and blood
-
blood urea nitrogen
results from catabolism and deamination of amino acids
-
plasma creatine
catabolism of creatine phosphate in skel foundation
-
loop diuretics
inhibit Na+ symporters
-
thiazide diuretics
inhibit Na+ symporters in collecting duct
-
treatment for kindey failure
continusous dialysis, kidney replacment
-
-
-
milliequivalance
measure concentrations of ions in body fluids
-
calcium
- most abundant mineral
- prathyroid and calcitonin
- blood clotting, neurotransmitter
-
magnesium:
cofactor for some enzymes
-
chloride:
anion, travels w/ sodium
-
-
phosphate
- bones, teeth, ATP, nucleic acids
- parathyroid and calcitrol
-
potassium deficiency
- shallow respiration
- changes in elctrocardiogram
- flattening of T wave
-
excesss of K+
- weakness
- ventricular fibrillation
-
CO2 plays major role in ________ balance
acid-base
-
buffer systems
bind to H+, can also release it again
-
bicarbonate
does not functionwell in respiratory dieases
-
normalizing blood pH
respiratory compensation
-
respiratory acidosis
- too much CO2
- to reverse: kidneys raise blood pH by eliminating H+
-
respiratory alkilosis
- not enough CO2
- to reverse: breath into bag
-
metabolic acidosis
- low HCO3-
- to reverse: hyperventilate
-
metabolic alkalosis
- to much HCO3-
- to reverse: hypoventilation
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