female repro 3

Brenner Tumor 

• Adenofibromas, unilateral, 
• –Nests of transitional cells ~ urinary bladder

–Fibrous stroma ~ normal ovary

Mature (Benign) Teratomas

• Mature (Benign) Teratomas
• •known as dermoid cysts

•Origin: Ectodermal differentiation of totipotential cells

•Age: In young women during active reproductive years

Immature (Malignant) Teratomas

• –In pre pubertal adolescents and young women
• Varying amounts of immature tissue
• differentiating toward cartilage, glands, bone, muscle and nerves

Monodermal or Specialized Teratomas

• –Struma ovarii: Composed of thyroid tissue: Can be functional leading to hyperthyroidism
• –Carcinoid 
• •Origin- Intestinal epithelium in a teratoma

•Produces 5-OH-tryptamine

• •Causes carcinoid
• syndrome

Dysgerminoma

•All dysgerminomas are malignant

•Half of malignant germ cell tumors

•Age–In childhood

• Dysgerminoma
• •PLAP bc counterpart of seminoma of testis
• •inc. HCG 
• •associated with Turner Syndrome

Endodermal Sinus (Yolk Sac) Tumors

• •2nd most common malignant tumor of germ cell origin
• •Rich in alpha-fetoprotein and alpha1-antitrypsin
• •Schiller-duval body
• •Glomerulus like structure

• Granulosa -Theca Cell Tumors
• •postmenopausal women
• •Yellow coloration Hormonally
• active tumors; produced by contained lipids

• Granulosa -Theca Cell Tumors
• •Granulosa cell component

• •Call-Exner bodies Can elaborate large
• amounts of estrogen

Chances of malignancy in granulosa cell forms

Elevated tissue/serum levels of inhibin

• Sertoli-Leydig Cell Tumors (Androblastomas,
• Arrhenoblastoma)
• •Is androgen secreting

•Symptoms of virilization (masculinization)

•C/S- Characteristic yellow-tan color

• Tumors Metastatic to ovary
• •Krukenberg tumors

•Krukenberg tumors

• Complete Mole
• •No fetal parts are identified

• Complete Mole
• •No fetal parts are identified

• Partial Mole
• •Pathogenesis
• –Triploid (69,XXY) or tetraploid (92,XXXY)
• Uterine cavity filled with a
• delicate, friable mass of thin-walled, translucent, cystic, grapelike
• structures [ swollen edematous (hydropic) villi]

Partial Mole

• Choriocarcinoma
• •Epithelial malignant neoplasm of trophoblastic cells
• –Large pale areas of ischemic
• necrosis

• Choriocarcinoma
• •Titers of HCG

Placental site trophoblastic tumor

–Beta HCG levels may be high

–Biomarkers (Mel-Cam and Ki-67) detect increased proliferation in trophoblastic cells