female repro 2

Adenomyosis

Endometrial Polyps

• •Associated factors
• –Hyperestrogensim
• or tamoxifen
• therapy

• Endometrial hyperplasia
• (Endometrial intraepithelial neoplasia)

• –Mutations
• in PTEN gene

Complex endometrial hyperplasia

• •Localized polypoid
• tumor

• •Diffuse tumor involving entire
• endometrial surface.

Adenocarcinomas

Leiomyomas (fibroid)

Leiomyomas (fibroid)

Leiomyomas (fibroid)

Leiomyomas (fibroid)

• •Individual
• muscle cells

• –uniform
• in size and shape

• –Characteristic
• oval nucleus

• –Long,
• slender bipolar cytoplasmic processes

Leiomyosarcomas

very rare

Leiomyosarcomas

• •Distinction of leiomyosarcomas from leiomyomas
• –Based on combination of degree of nuclear atypia, mitotic index, and zonal necrosis

Paratubal Cysts

• •Paratubal cysts
• (para-ovarian cysts)

•Hydatids of Morgagni

• Polycystic ovaries
• –(PCOD, Stein-Leventhal syndrome)

PCOD

PCOD

•Thickened superficial cortex

• •Beneath- Many follicle cysts with
• hyperplasia of theca interna (follicular hyperthecosis)

Serous tumor of ovary

• Papillary serous tumor (Borderline/
• Malignant)

• •Serous cystadenoma: 
• Lining epithelium –

• –Columnar
• epithelium with abundant cilia in benign tumors

• •Tumors
• of borderline malignancy:

• –Increased complexity of stromal
• papillae

• –Stratification of epithelium;
• nuclear atypia

• –Infiltrative growth into stroma
• is not seen

•Serous papillary Cystadenocarcinomas: Complex branching; Invasion

•Psammoma bodies: In any papillary lesion

Serous papillary Cystadenocarcinomas:

Mucinous Tumors

• –Multiloculated tumors
• –Filled with sticky, gelatinous fluid
• –Rich in glycoproteins

–Tall columnar epithelial cells

–Apical mucin

–Absence of cilia

•Borderline

•Malignant

Pseudomyxoma Peritonei

Pseudomyxoma Peritonei

• Histology
• of peritoneal implants from an appendiceal
• tumor, showing mucin-producing epithelium and free mucin (arrows)

Endometrioid Tumors

Endometrioid Tumors