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diabetes

  1. repaglinide
    prandin
  2. nateglinide
    starlix
  3. MOA of meglitinides
    Katp channel modulators (insulin secretagogues)
  4. onset and DOA of meglitinides compared to SUs
    quicker onset, shorter DOA
  5. biguanides MOA
    increase activity of AMPK (insulin sensitizers)
  6. what are the insulin sensitizers
    • biguanides/TZDs
    • metformin
    • pioglitazone
    • rosaglitazone
  7. at what Scr lvs for men and women should Metformin be avoided
    • > 1.5 for men
    • > 1.4 for women
  8. when is metformin contraindicated
    • kidney 
    • acute HF
    • contrast (can cause acute kidney injury)
  9. januvia
    sitagliptin
  10. tradjenta
    linagliptin
  11. saxagliptin
    onglyza
  12. classes of insulin secretagogues
    • SUs
    • Meglitinides
    • DPP IV inhibitors
  13. class of insulin secretagogues that are absolute glucose dependent
    DPP IV inhibitors
  14. glyburide
    • diabeta
    • glynase
    • PresTab
  15. amaryl
    glimepiride
  16. glucotrol
    glipizide
  17. which SU has active metabolite
    glyburide
  18. hypoglycemia is seen more in which SU with renal insufficiency
    glyburide
  19. how is glimipiride dosed
    QD before first meal
  20. SE of SUs
    • hypoglycemia
    • wt gain
  21. glyset
    miglitol
  22. precose
    acorbose
  23. SE of pioglitazone
    • increase risk of fractures
    • bladder cancer
    • edema
  24. Sulfonylureas MOA
    bind to SUR on the beta cell K channel complex and inhibits activity
  25. MOA of TZDs
    ligand for PPARy receptor which are involved in the regulation of glucose and lipid metabolism
  26. effects of TZDs
    • promote uptake of FA
    • increase tissue sensitivity to insulin
  27. Byetta
    exenatide
Author
Anonymous
ID
268586
Card Set
diabetes
Description
Agbahiwe/Hayes
Updated

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