Onco exam 3 Schiff sources/chemistry

Source: semisynthetic derivative of sirolimus; rapamycin derivative

Type: macrolide; rapamycin derivative

Properties: colorless solid; no ionizable functional groups; water insoluble

Source: semisynthetic derivative of polyketide macrolactone (Epothilone B); isolated from myxobacterium from edge of Zambezi River

Type: macrolactam; thiazole + macrolide ring

Properties: no ionizable functional groups; neutral lactam N; thiazole N electrons delocalized (no salt formation); solubility by incorporation into castor oil and alcohol

Source: dried rhizones and mayapple/American mandrake; part of a mixture of resins

Type: lignan (dimeric phenylpropanoid)

Properties: biologically activity dependent on lactone ring exisiting in trans-configuration

Source: semi-synthetic lignan of derivative of podophyllotoxin

Type: phosphate ester

Properties: phosphate ester lessens volume of solution administered and time of administration

Source: fruits of Ammi visnaga, a Mediterreanean

Type: furancocoumarin

Properties: pale yellow; low water solubility; effects enhanced following exposure to UV-A

Source: seeds of plant Euphorbia lathyris; sap of plant Eurphorbia peplus

Type: diterpene alcohol; also a tetraol

Properties: 4 x C5 units; contains angelic acid

Source: metabolite of retinol; prepared by oxidation of retinal

Type: carotene derivative

Properties: lipophilic; low water solubility

Sources: derivative of Vit A; biosynthesis from all trans retinoic acid

Type: carotene derivative

properties: lypophyilic, low water solubility

second gen retinoid used for therapy of severe psoriasis in adults

derivative of retinoic acid

Source/Type: a rexinoid:

properties: synthetic, lipophilic, weak acid

Source: purified product of a hematoporphyrin derivative

Type: light-sensitive polyporphyrin oligomer

properties: red-orange color; made of ppyrrole rings

source: fermentation of streptomyces antivioticus

type: 2'-deoxycoformycin (DCF)

properties: colorless nucleoside, weak base, water soluble, contains inosine

Source: fermentation product of E. coli and Erwina carotovoras

Type: enzyme made of 4 identical subunits

Properties: white, water soluble, active at ph 5-9

Source/type: various ores (e.g. orpiment); by product of smelting copper; Pi Shuang in traditional chinese medicine

properties: white solid, 2 mineral forms (arsenolite and claudetite), slowly soluble in water

source: metabolite of parasitic fungus Nocardia that infects ethiopian shrub Maytensus ovatus

Type: ansa macrolide-type antibiotic

properties: aromatic ring system spanned by alphatic chain/bridge