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  1. What drugs induce CYP 450 and thus you should be e cautious using with oral contraceptives?
    • Rifampin, antiepileptic drugs, anti-HIV drugs, St. John’s Wort
    • Potentially broad spectrum antibiotics
  2. What drugs can Oral contraceptives inhibit the hepatic metabolism of?
    Tricyclic antidepressants or diazepam
  3. What type of drugs may be less effective with oral contraceptives?
    Warfarin or hypoglycemic agents
  4. What are the Estrogen RT drugs?
    • Conjugated equine estrogens (CEE) [Premarin]
    • Micronized estradiol [Estrace]
    • Estropipate (piperazine estrone sulfate)
    • [Ortho-est] Ethinyl estradiol
  5. What are the estrogen therapies for women with or without a uterus to prevents vaginal atrophy?
    • Conjugated equine estrogens (CEE) [Premarin]
    • Estradiol cream [Estrace]
    • Estradiol acetate [Femring]
    • Estradiol hemihydrate tablets [Vagifem] (inserted)
  6. What are the CI’s for ET?
    • vascular disorders
    • thromboembolic disease
    • ischemic stroke
    • myocardial infarction
    • estrogen dependent breast, ovarian, endometrial cancers
    • impaired liver function
    • pregnancy
    • undiagnosed genital bleeding
    • gall bladder disease
    • hypertriglyceridemia
  7. What are the progestin only replacement therapy drugs?
    • megestrol acetate (Megace)
    • medroxyprogesterone acetate (MPA)
  8. What are the adverse effects of PT?
    • vaginal bleeding
    • fluid retention
    • increased appetite
    • breast tenderness
    • acne
    • hirsutism
    • headaches, mood swings, depression
    • fatigue
  9. What groups would you not want to use PT in?
    • Obese
    • Chronically depressed
  10. Which PT therapy would you use for cancer patients to help aid the remission?
  11. What are the benefits of EPT vs PT or ET?
    It’ll prevent endometrial cancer
  12. What drugs may be used for their serotoneric effects to help with hot flashes and vasomotor effects of menopause?
    • Venlafaxine, fluoxetine, paroxetine, sertraline
    • May not work
  13. gabapentin (Neurontin), an amino butyric acid analogue, is used to treat what symptoms of menopause (not usually successful)?
    Hot Flashes
  14. What antihypertensive would be used for Menopausal sysmptoms of hot flashes?
    Clonidine (not very effective)
  15. How is it proposed that Clonidine (antihypertensive) reduces hot flashes?
    Reduces sympathetic outflow
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