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Adhesion Receptors:
- G-protein class: none
- Protein kinase type: depends on the pathway
- Second messenger: none
- Most phosphorylation on Tyr/Ser/Thr: --
- Major end response: motility/adhesion
- Unique element(s): Ligands for receptors are extracellular matrix components.
-
Gated Ion Channels
- G-protein class: none
- Protein kinase type: usually none
- Second messenger: none
- Most phosphorylation on Tyr/Ser/Thr: --
- Major end response: ion moved across membrane.
- Unique element(s): one system that actually has molecules passing through receptor.
-
G-protein Couples Receptors
- G-protein class: heterotrimeric
- Protein kinase type: PKA or PKC
- Second messenger: cAMP, DAG, Ca2+, IP3
- Most phosphorylation on Tyr/Ser/Thr: Ser/Thr
- Major end response: change in metabolic activity.
- Unique element(s): All serpentine receptors are in this system. Several different second messengers.
-
Nuclear Receptors (Steroid Receptors)
- G-protein class: none
- Protein kinase type: none
- Second messenger: none
- Most phosphorylation on Tyr/Ser/Thr: --
- Major end response: change in gene expression (+/-).
- Unique element(s): Receptors in nucleus, ligand passes through membranes.
-
Receptor Tyrosine Kinases
- G-protein class: low molecular weight
- Protein kinase type: Tyr Kinases
- Second messenger: none
- Most phosphorylation on Tyr/Ser/Thr: Tyr
- Major end response: change in metabolic activity or gene expression.
- Unique element(s): Only type with autophosphorylation, receptor itself has enzyme activity.
-
Receptor Guanylyl Cyclase
- G-protein class: Heterotrimeric
- Protein kinase type: PKG
- Second messenger: cGMP
- Most phosphorylation on Tyr/Ser/Thr: Ser/Thr
- Major end response: change in metabolic activity.
- Unique element(s): Only systems to use cGMP and Guanylyl cyclase, soluble and membrane receptors.
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