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What is the MOA of TCAs?
Inhibit the reuptake of NE and Serotonin in the CNS
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TCAs are used to treat what disorder?
Panic disorder, Enuresis, Neuropathic pain and Depression
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What receptors can TCA’s interact with?
SERT (serotonin), NET (NE), Histamine, Muscarinic (1 and 2), alpha-1-adrenergic, some: voltage gated ion channels
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What drug is the most selective inhibitor of serotonin reuptake studied to date?
Escitalopram
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What is Fluoxetine/Prozac indicated for?
Depression, PMDD, Bulimia and Geriatric depression
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Does Fluoxetine/Prozac have a long or short half life?
Long
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What is Sertraline (Zoloft) indicated for?
PTSD, PMDD, OCD in children, Major depressive disorder
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Which SSRI has one label indication and what is the indication?
Citalopram, Depression ( though used for OCD and other SSRI indications)
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Cymbalta (Duloxetine)
SNRI
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Svella (milnacipran)
SNRI
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Effexor (venlafaxine)
SNRI
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Pristiq (desvenlafaxine)
SNRI
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Edronax (reboxetine)
NaRI
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