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micro ch 6
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what are some characteristics of ideal antimicrobial drug?
microbicidal and not microbistatic
soluble, penetrate through
potent long enough
not subject to antimicrobial resistance
assists activities of host defense
remains active in tissues
not costly
some antibacterials that inhibit cell wall synthesis
glycopeptides
amoxcillin
Beta-lactams
vancomycin
bacitracin
fosfomycin
cycloserine
types of Beta-lactams
penicillins
cephalosporins
carbapenems
monobactams
cephamycins
Beta-lactamase inhibitors
clavulanic acid + amoxycillin
sulbactam + ampicillin
tazobactam + piperacillin
some antibacterials that inhibit protein synthesis
aminoglycodies
tetracyclines
erythromycin
clindamycin
chloramphenicol
types of aminoglycosides
gentamicin
tobramycin
amikacin
neomycin
streptomycin
Beta-lactams are more active against gram pos or gram neg?
gram pos
How can inhibitors of protein synthesis not effect us?
different ribosomes
How do inhibitors of protein synthesis work?
mRNA is misread
peptide bond is blocked
anticodon on tRNA is blocked (prevents initiation of protein synthesis)
What are the mechanisms of drug resistance?
drug inactivation
decreased permeability
activation of drug pumps
use of alternate metabolic pathways
choosing which drug to take:
health status of patient
receptor site & binding proteins
mixture of IV
how would an antimicrobial reach the site of infection?
at inhibitory concentratoins
the antimicrobial
penetrates
and
binds
to target, avoiding what?
inactivation and extrusion
what are the for possible target sites for antibacterials?
cell wall synthesis
protein synthesis
nucleic acid synthesis
cell membrane function
dissemination related to mutant selection
chromosomally-mediated resistance
dissemination related to spread of resistance plasmid
plasmid-mediated resistance
what is dissemination of resistance genes?
how resistance genes spread out throughout the area
Author
stef1208
ID
26116
Card Set
micro ch 6
Description
micro ch 6
Updated
2010-07-09T17:11:49Z
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