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actions/responses of adrenergic drugs
- purpose of stimulatin sympathetic(adenergic) nerves is to divert blood flow to vital organs so body could deal w/ stress
- CNS- wakefulness, fast reaction 2 stimuli, fast reflexes
- ANS-relaxation of smooth musclesof bronchi, constriction of blood vessels, sphincters of stomach, dialation of coronary blood vessels, decreases gastric mobilty
- HEART- increases HR
- METABOLISM- increase use of glucose & liberation of fatty acids from adipose tissue
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Adrenergic nerve receptors
degree to which any organs is affected by sympathic nervous system depends on which postsynpathic nerve receptor site are activated
adrenergic nerves: alpha or beta receptors
drugs act as selective acts on A or B receptors, nonselective act on both
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Effects of Adrenergic receptors
- A1- peripheral blood vessels- effects vasoconstriction of peripheral blood vessels
- A2- presynaptic- regulates release of neurotransmitter, decrease tone, motility & secretions of GI tract
- B1- myocardium- increasesd HR & force of myocardial contration
- B2- peripheral blood vessels- vasdialation of peripheral vessels
- bronchial smooth muscle- bronchodilation
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Adrenergic Drug Uses:
- hypovolemia & septic shock, allergic reaction(anaphylactic shock, angioneurotic edema), ventricular arrhythmias
- control of superficial bleeding during surgical & dental procedures of mouth, nose, throat, skn, nasal, congestion, & glucoma
- cardiac decomposition & arrest
- temp. tx of heart block
- used as a bronchodialator
- vasoconstricting adjunct to anethetics to prolong it
- shock- inadequate tissue profussion
- *symptoms- supply of aterial bolld oxygen flowing to cells & tissue is inadequate
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types of shock
hypovolemic shock,carddiogenic shock,distributive shock
- shock results:
- decrease in cardiac output,hypoxia,decrease in arterial blood pressure;reabsorption of water by kidneys
- increase in carbon dioxide in blood,decrease in oxygen in blood increased concentration of intravascular fluid in cardiogenic shock adrenerginic drug may b used w/ a vasodialating drug
- vasodialator- improves myocardial performance, adrenergenic maintains b/p
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AR
depends on the drug, dose, & pt
- cardiac arrhythmias
- headache
- nausea, vomiting
- high b/p
epinephe
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