micro ch 8

  1. Secondary response is the same as _____.
    anamnestic response
  2. There is the same amount of ___ in primary response as there is in secondary response. What increases in secondary response? Why?
    IgM stays the same. IgG increases due to memory cells.
  3. What is the first line of defense? When does it set in?
    • intact skin
    • mucous membranes and their secretions
    • sets in immediately
  4. What is the second line of defense? When does it set in?
    • phagocytic white blood cells (neutrophils)
    • inflammation
    • complement
    • fever
    • sets in a minute to an hour
  5. What is the third line of defense? When does it set in?
    • B&T lymphocytes
    • antibodies
    • sets in 10-14 days
  6. What is nonspecific defense?
    • innate (born with it)
    • 1st and 2nd lines of defense
  7. What is specific defense?
    • learned
    • 3rd line of defense
    • once it sees one organism, there is an immediate response when it shows up again
  8. What are the blood borne molecules part of innate immune system?
    • acute phase proteins
    • complement
    • tumor necrosis factor
  9. What are the 2 major mediators of inflammation?
    • histamine
    • Bradykinin
  10. histamine and Bradykinin are released by what?
    mast cells
  11. What are the steps of phagocytosis?
    • 1. attachment (to pseudopods)
    • 2. ingestion (of bacteria forming phagosome, moves toward lysosome)
    • 3. fusion (of phagosome and lysosome)
    • 4. digestion (or bacteria into nucleotides, peptides)
    • 5. release (of peptides into surrounding environment)
  12. most important killing mechanism
    superoxide generation (H2O2)
  13. What can T-Lymphocytes destroy?
    • intracellular microbes
    • malignant cells
    • cells of transplanted organisms
    • self cells (autoimmune disease)
  14. Which TH cell produces cytokines and is part of cell-mediated immune response?
  15. Which TH cell produces cytokines and is part of humoral response?
  16. Which organs are the one in which lymphocytes arise and mature (bone marrow, thymus, etc)?
    generative organs
  17. Which organs are the sites where mature lymphocytes respond to foreign antigens (lymph nodes, spleen, mucosa associated lymphoid tissues and cutaneous immune system)?
    peripheral organs
  18. cardinal features of immune responses
    • 1. specificity
    • 2. diversity
    • 3. memory
    • 4. self-regulation
    • 5. discrimination of self from non-self
  19. an antigen molecule must have:
    • foreignness
    • high molecular weight
    • chemical complexity
  20. classes of anitbodies
    • IgG
    • IgM
    • IgA
    • IgE
    • IgD
  21. IgM is not involved in ____ and is only for the production of ___.
    memory; IgG
  22. treatments for allergies
    • avoidance
    • antihistamines, cortisone
    • stabilize mast cells
    • therapy to bind up IgE (in extreme cases, young children)
  23. hypersensitivity type that is IgE mediated
    type I
  24. hypersensitivity that is IgG/IgM mediated
    type II
  25. hypersensitivity related to immune complex (Ab/Ag)
    type III
  26. hypersensitivity that is delayed; related to poison ivy, cheap jewelry, etc
    type IV
Card Set
micro ch 8
micro ch 8