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There is a ___________ therapeutic index on drugs for HIV for children
narrow
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HIV infected women should not
breastfeed
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what is used to prevent maternal transmission of HIV to fetus?
AZT
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HIV replication can be ______ but not ______
controled
cured
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Influenza
Protoype: rimantadine (Flumadine)
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- MOA: prevents shedding of the outer viral coat of the virus
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- Caution: People who have renal disease may have sensitivity
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- Adverse effects: Orthostatic hypotension, insomnia, dizziness, urinary retension
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- Must be given early in course for treatment to be effective with 24-48 hours of symptoms
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Herpes/Cytomegalovirus
Prototype: acyclovir (Zovirax)
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- MOA: affects DNA replication
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- Caution: can’t use in pregnancy or lactation, caution with renal disease, at best safety in children not established- at worst carcinogenic
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- Adverse: N/V, HA, depression, rash, hair loss
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- Might be given to prevent outbreak
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_____ is an antigen on the surface of T helper cells that is the primary receptor for HIV which results in HIV primarily infecting _____ positive T helper lymphocytes.
CD4
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Highly Active Antiretroviral Therapy (HAART)
uses atleast 3 drugs
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Adverse effects of HAART drugs:
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- Adverse effects of these medications:
- Lipid disorders- elevate cholesterol
- Increased risk of diabetes
- Increased cardiovascular diseases
- Increased risk of osteoporosis
- At risk for nephrotoxicity
- *Multiple drug interactions
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Atripla is what
most common first line therapy for HIV. Has 3 drugs in it
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