Drug Protocols

  1. Presentation of Ceftriaxone
    1gm powder in an ampoule
  2. Indications of Ceftriaxone
    Suspected meningococcal septicaemia with evidence of petichial or purpuric rash consistent with meningococcal septicaemia and headache, +/- hypotension and/or tachycardia
  3. Contra-Indications of Ceftriaxone
    Known anaphylaxis or severe allergic reaction to penicillin based drugs (not minor rash)

    Know allergy to cephalsporin drugs
  4. Side effects of Ceftriaxone
    • Nausea
    • Vomiting
    • Pain at the administration site
  5. Dosage of Ceftriaxone - Adult
    IM -1gm diluted with 3.5ml of normal saline (results in total volume of 4ml)

    IV - 1gm diluted with 9.5ml of normal saline, administered slowly over 2 minutes and flushed with normal saline.
  6. Dosage of Ceftriaxone - Child
    IM - 1gm powder mixed with 1.5ml normal saline (total volume 2ml) then administer volume according to specified weight ranges:

    • Weight less than 5kg = 0.5ml
    • 5-10kg = 1ml
    • 10-15kg = 1.5ml
    • 15-20kg = 2ml
    • greater than 20kg = 2ml (max dose 1 gm)

    IV - 1gm diluted with 9.5mls of normal saline (results in a volume of 10ml = 100mg/ml) Once mixed, administer 50mg/kg (0.5ml/kg) slowly over 2 minutes

    Greater than 20kg max dose = 1gm (1000mg)
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Drug Protocols