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Definition of Virus
Small, infectious, obligate intracellular parasite capable of replicating within host cell
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Properties of Virus
- Genome: RNA or DNA
- Directs synthesis of virion components within appropriate host cell
- Progeny made exclusively of newly made components
- Progeny spread and infect new cells
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Common steps in life cycle of all viruses
Attachment, Penetration, Uncoating, Biosynthesis of new genome/proteins, assembly, and release
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What ultimately determines a specific viruses pathogenicity?
How well the host cell responds.
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Removal of apoptotic inhibitors does what to a viruses virulence
Decreases it, cell can now an hero and save day
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Edward Jenner
Small pox/cow pos inoculation
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Koch's Postulates work perfectly for viruses
False
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Current area of virus research it in regard to what?
Molecular pathogenicity
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HIV is a ___ virus
envelope
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Routes of human infection
Conjunctiva, Mouth/Nose, Respiratory tract, Capillary, Anus, GT, UT
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Viruses have what kind of locations for replication
Specific
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One step growth curve:
- Eclipse period: time when no virus found
- Latent period: Virus found withen cells, not in media
- Eventually release virus>cellular virus because all cells dead
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PFUs=
Plague forming units
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In many viruses the negative health effects are from what
Immune response (innate)
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Viruses are classified by:
- Viral genome (RNA or DNA)Capsid (shape or outer proteins)
- Lipid membrane presence (Envelope)
- Size
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- Based on Disease caused
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- Baltimore Classification system
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Largest virus
Pox/Bactovirus
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Baltimore Classification system
- Based on what the initial genetic material is (And how it becomes +RNA that codes):
- I- +/- DNA
- II- +DNA
- III- +/- RNA
- IV- +RNA that turns into - RNA
- V- -RNA
- VI- +RNA that turns into -DNA
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