this subtance is the mediator of the inflammatory process
this enzyme aids in prostaglandin synthesis
Anti-inflammatory meds include:
what can be done to avoid drug interactions/ adverse effects?
Use alternate methods
use submax doses of multiple meds
COX enzyme --> prostaglandin synthesis --> mediation of inflammatory process
How does aspring work in this process?
asprin inhibits COX therefore decreasing inflammation
Indications for asprin:
Anti-platelet: inhibits platelet COX enzyme
NSAIDS is a non-selective COX inhibitor therefore inhibits both COX-1 (good) and COX-2 (bad) enzymes.
what is the differnce between asprin and NSAIDS?
asprin is also an anti-platelet NSAIDS are not.
this anti-inflammatory drug may cause edema especially in patients with renal dysfunction and heart disease.
COX-1 inhibition --> decreased urine output --> fluid retention and edema
COX-2 inhibitors were discontinued due to fatal cardiac effects. these included:
these drugs are potent anti-inflammatories:
these are naturally occurring anti-inflammatories from the adrenal cortex
Indications for glucocorticosteriods:
these drugs inhibit parts of the inflam process including:
leukocyte and macrophage migration to area
review of anitinflammatory drugs