pharmacokinetics.txt

percentage of medication that reaches the systemic circulation

Name the 7 ways drugs can be absorbed into the body:

drugs absorbed through this route

- must be lipid soluble
- are absorbed through passive diffusion

drugs absorbed through this route:

- can not be taken orally because will be destroyed by stomach acid

drugs absorbed through this route:

- are delivered directly to site of action via small particles
- have minimized side effects

drugs absorbed through this route:

- have rapid absorption
- should avoid high fat distribution which can slow down absorption

Drugs absorbed through this route:

are consistent, reliable with good bioavailability

drugs absorbed through this route:

have instantaneous systemic absorption

Pharmokinetic terms for drugs
: % of med that reaches systemic circulation

: method by which drug is administered into body

: method by which drug gets to site of action

: elimination of drugs to maintain proper levels of medications

: clearance of drug from the body by volume of blood/unit of time

Distribution ( drugs ability to get to site of action) is affected by:

1) local blood flow

2) plasma protein binding

enzymes in liver transform drugs to less active or inactive drug compounds or to another substance.

: this drug is inactive when administered and metabolized into an active form by the liver.

this is a phenomenon occurs when an oral drug is metabolized by the liver before it enters the systemic circulation therefore decreases bioavailability.

drug elimination occurs in this organ

the amount of time it takes for plasma concentration to drop to 50%

drugs and receptors/receptor sites:

:endogenous substances and drugs that bind with appropriate receptors to produce some effect.

: ability to cause a response at a receptor site

: comparing two drugs and their ability to produce the same response.

: subtances or drugs that fit into and bind to receptor sites to block the receptor and not allow it to be activated.

have an affinity for site but no efficacy
therapeutic in that they may increase or decrease a certain biological process