Transport mediated by a membrane transport protein; three types: uniport, symport, antiport. Used to transport molecules that cannot pass through membrane by simple diffusion (too large, lipophobic or electrically charged)
Mediated Transport
Passive and moves molecules down their concentration gradient and the net transport stops when concentrations are equal on both sides of the membrane; requires no input or energy from outside source.
Facilitated Diffusion
Moves molecules across membranes; two types: channel proteins and carrier proteins.
Transporters
Create water-filled passageways that link intracellular and extracellular compartments.
Channel Proteins
Carriers that bind to a substrate that they carry.
Carrier Proteins
Channels that are made from a protein called aquaporin.
Water Channels
Channels that may be specific for one ion or may allow ions of similar size and charge to pass.
Ion Channels
Channels that allow ions to move back and forth across the membrane without regulation; also called leak channels.
Open Channels
Channels that spend most of their time closed which allows the channels to regulate the movement of ions through them.
Gated Channels
Channels that use intracellular messenger molecules or extracellular ligands to control the gating.
Chemically Gated Channels
Gating that is controlled by the electrical state of the cell.
Voltage Gated Channels
Gating that can be controlled by any physical change.
Mechanically Gated Channels
Carrier proteins that move only one kind of molecule.
Uniport Carriers
Carrier that moves more than one kind of molecule.
Cotransporter
Molecules being transported that are moving in the same direction whether into or out of the cell.
Symport Carriers
Molecules that are being transported in the opposite direction of each other.
Antiport Carriers
The energy used to push molecules against their concentration gradient that comes directly from the high energy phosphate bond of ATP.
Primary Active Transport
Potential energy stored in the concentration gradient of one molecule is used to push other molecules against their concentration gradients.
Secondary Active Transport
The point at which increases in concentration do NOT result in an increase of movement of a substance across the membrane.
Transport Maximum
The ability of a carrier to move one molecule or only a group of closely related molecules.
Specificity
A transporter may move several members of a related group of substances but those substrates will compete with one another for the binding sites on the transporter.
Competition
Rate that depends on both the substrate concentration and the number of carrier molecules.
Saturation
Regions of protein molecule that open and shut controlling flow.
Gates
Diffusion that happens directly across the phospholipid bilayer.
Simple Diffusion
Ingestion of bacteria or other material of phagocytes.
Phagocytosis
Vacuole in cytoplasm of cell containing a phagocytosed particle enclosed within a part of the cell membrane.
Phagosome
Ingestion of a liquid into a cell by the budding of small vesicles from the cell membrane.
Pinocytosis
Process by which cells internalize molecules by the inward budding of plasma membrane vesicles containing proteins with receptor sites specific to the molecule being internalized.
Receptor Mediated Endocytosis
Reuse of the ligands receptors.
Membrane Recycling
Intracellular vesicles move to cell membrane and fuse with it; then their contents are released to extracellular fluid.
Exocytosis
Combination of endocytosis, vesicular transport across the cell, and exocytosis; macromolecules that are transported across interior of cell.
Transcytosis
Taking in of matter by a living cell by invagination of its membranes to form a vacuole.