Exercise Physio LECTURE 1.txt

  1. Initiating, Integrating and Controlling Movements
    Cerebrum - responsible for higher mental functions, movement, visceral functions, perception, behavioral reactions, and for the association and integration of these functions. 

    Motor Cortex - consists of the primary motor cortex and the premotor cortex

    Premotor Cortex - causes general patterns of movement involving groups of muscles that perform specific tasks. Involved in the unconscious fine tuning of muscle activity required for highly-skilled movements.

    Sensory Cortex - relays information into the motor cortex for control of motor activities

    Basal Ganglia - functions in muscle tone, control of movement

    Thalamus - acts primarily as a relay station of sensory input as well as interpretation of some sensory input, such as pain, temp, crude pressure and touch

    Cerebellum - coordination of movement

    Medulla Oblongata - controls heart rate, blood flow, equilibrium, swallowing, salivation and respiration

    Pons - controls respiration; also involved in facial/neck sensations and the regulation of facial expressions, eye movement, taste, salivation and equilibrium.

    Midbrain - conveys sensation of touch, proprioception and vibrations to the thalamus; also, involved in the regulation of eye movement, pupil size and lens shape.

    Pyramidal System - Of the pyramidal motor tracts, 90% cross-over at the decussation of pyramids and 10% are ipsalateral

    Extrapyramidal System - general movement patterns (i.e., muscle tone and posture, control of head movement to vision and hearing, and equilibrium), highly-skilled movements which facilitate the execution of whole movement patterns without conscious awareness of the individual parts (i.e., allows for fine tuning)

    Sensory receptors that provide feedback to the CNS include:

    • Muscle Spindles
    • Golgi Tendon Organs
    • Bulbs of Krause
    • Pacinian Corpuscles
    • Ruffini End Organs 

    Limbic System - provids input to the motor cortex regarding motivation drives and needs
  2. Ipsalateral Training
    "descend along the same side/do not cross-over)

    occurs when only one side of the body is developed through motor training, but due to a cross-transfer effect the other side of the body does receive some neural stimulus and hence, is developed to some extent.
  3. Joint Receptors
    provide sensory information regarding joint angle, acceleration at the joint, and the degree of deformation brought about by pressure.

    Greatly contribute to kinesthetic awareness because they prodvide info regarding body awareness

    Pacinian corpuscles detect changes in vibrations

    Ruffini corpuscles detect changes in temp
  4. Proprioceptors
    in general, sense position, length, tension, pressure and temp in a muscle and hence, regulate rate of change in length as well as facilitating kinesthetic awareness.
  5. Golgi Tendon Organs
    proprioceptors located in muscles at their junctions with tendons and in ligaments of joints; if force of contraction and consequently tension is too great, inhibits alpha and gamma motor neuron of contraction muscle thereby reducing excess tension and thus preventing injury (protective mechanism - reflex inhibition).

    Also, appear to help equalize the contractile forces of seperate muscle fibers.
  6. Roles of the Muscle Spindle
    proprioceptors located in intrafusal muscle fibers which lie parallel to the extrafusal (normal) muscle fibers.
  7. Roles of the Intrafusal Fibers
    involved in gross muscular contraction
  8. Roles of the Gamma Motor Neurons
    activate the intrafusal muscle fibers
  9. Roles of the Annulospiral Endings
    sensory receptors that detect the length or stretch on the intrafusal muscle fibers
  10. Roles of the Sensory Afferent Neurons
    receives and carries information from annulospiral endings via spinal cord
  11. Three Functions of Muscle Spindles
    • (1) sense length of fibers
    • (2) reflex contraction
    • (3) coavtivation
  12. Motor Unit
    a motorneuron and all the muscle fibers that it innervates

    • -each is the same in fiber type composition (either SO, FOG, or FG - no mixtures)
    • -each type differs in sensitivity to stimulation (SO is easiest, FG is hardest - size principle)
    • -each operates on "all-or-none" principle
    • -all fibers in motor unit are equally sensitive to neural stimuli

    Force Production Determinants

    • -dependent on actin and myosin bonding*
    • -# of fibers w/in active motor units (hyperplasia will increase fiber #)
    • -# of motor units activated
    • -size of fiber wi/in active motor units (hypertrophy)
    • -balance between stimulating and inhibiting hormones
    • -frequency of impulses
    • -speed of movement and fiber type
  13. Roles of Extrafusal Muscle Fibers
  14. Roles of Alpha Motor Neurons
    innervate the extrafusal muscle fibers
  15. Physiological Characteristics of a Motor Unit
  16. Neuron
    a nerve cell
  17. Soma
    cell body of a neuron
  18. Axon
    process of a neuron that carries impulses away from the cell body
  19. Dendrite
    portion of a neuron that carries impulses toward the cell body
  20. Schwann Cell
    responsible for producing myelin
  21. Node of Ranvier and Saltatory Conduction
    portion of a myelinated axon which is not covered by myelin sheath

    important for saltatory conduction as impulse "jumps" from one Node of Ranvier to the next allowing for fast nerve impulse conduction
  22. Synapse
    the point of contact where nerve impulses are transmitted from one neuron to another
  23. Pre-Synaptic Membrane
    the membrane proximal to a synapse
  24. Post-Synaptic Membrane
    the membrane distal to a synapse
  25. Synaptic Cleft
    gap between pre and post synaptic membrane
  26. Synaptic Vesicle
    vesicles in the axon terminal where neurotransmitters are stored
  27. Acetylcholine
  28. Gamma Amino Butyric Acid
  29. Epimysium
    connective tissue surrounding a muscle; connects into tendon at the origin and insertion of the muscle
  30. Perimysium
    connective tissue surrounding a fasciculus or group of muscle fibers
  31. Endomysium
    connective tissue surrounding a muscle cell or fiber
  32. Sarcolemma
    muscle cell membrane
  33. Sarcoplasm
    cytoplasm of muscle cell; site of anaerobic metabolism
  34. Mitochondria
    site of cellular oxidation or aerobic metabolism; powerhouse of the cell
  35. Myofibril
    threadlike protein strands
  36. Sarcomere
    functional unit of the muscle cell; runs from Z line to Z line
  37. Actin
    thin protein myofilaments
  38. Myosin
    thick protein myofilaments
  39. Crossbridge
    also called S-1 heads; extend from actin and myosin
  40. S-1 Head of Myosin
  41. Tropomyosin
    long, thin molecules that lie on the surface of the actin strand
  42. Troponin
    globular molecules (tropomyosin molecules embedded)
  43. Z Line
    anchored to the sarcolemma

    • (1) anchors actin (pulling mechanism)
    • (2) keeps actin properly oriented around myosin (surrounding)
    • (3) provides pathway for T-tubule system to go deep into muscle tissue
  44. I Band
    light areas near the Z lines consisting of the thing, actin myofilaments
  45. A Band
    dark areas consisting of both the thin myofilaments and the thick, myosin myofilaments
  46. H Zone
    slight variation in the shading of the A band due to absence of the actin myofilaments
  47. T Tubules
    appear to parallel Z lines (invaginations of the cell membrane)
  48. Longitudinal Tubules
    run parallel to myofibrils
  49. Cisternae
    store Ca++
  50. In relationship to the sarcoplasmic reticulum, what is meant by the term "triad?"
    collectively, the two cisternae and T tubule are known as the triad
  51. What happens to the H zone and I band during muscle contraction?
  52. What is the basic functional unit of a muscle cell?
  53. Events of Muscle Contraction (1-1/1-1A)

    Relate events of muscle contraction to the sliding filament theory.
  54. 2 Roles of Calcium in Muscle Contraction*
    • (1) influx of Ca++ into the axon terminal stimulates the release of acetylcholine (contraction - step 1)
    • (2) binding of calcium to regulatory sites on troponin remove the inhibition between actin and myosin (contraction - step 4)
  55. 3 Roles of ATP in Muscle Contraction*
    • (1) the release of previously stored energy drives the power stoke of the myosin S-1 head resulting in the pulling (sliding) of actin over myosin (contraction - step 5)
    • (2) new molecule of ATP binds to myosin S-1 head causing the dissociation of actin and myosin; myosin ATPase breaks ATP down into ADP + Pi, heat, and energy which is used to tilt the myosin S-1 head back down and away from actin to the resting, relaxed position (contraction - step 6)
    • (3) ATP is used to actively pump Ca++ back into the sarcoplasmic reticulum cisternae when the nerve impulse stops (relaxation - step 1)
  56. How fast can muscle tissue twitch during sustained muscular contraction?
    twitches occur at the rate of 100-200 per second during sustained muscular contraction
  57. 3 Fundamental Principles of Exercise Physiology
    • (1) peak rate of muscle contraction (peak twitch rate) is dependent on myosin ATPase activity and the size (thickness) of the motor axon
    • (2) maximal force (tension) that a muscle can generate is dependent on the amount of actin-myosin binding that is taking place
    • (3) continuation of muscle contraction is dependent on the ability to recycle ATP
  58. What factors are peak rate of muscle contraction dependent on?
    speed of contraction dependent on

    • A. size of axon (myelination)
    • B. myosin ATPase; FT > ST

    FG > FOG > SO
  59. What factors is maximal force (tension) that a muscle can generate dependent on?
    maximum tension dependent on action-myosin binding; FT > ST

    FG > FOG > SO
  60. What factors are continuation of muscle contraction dependent on?
    continuation of muscle contraction is dependent on ability to recycle or regenerate ATP; ST > FT

    SO > FOG > FG
  61. Muscle Fiber Types
  62. How do muscle fiber types relate to the 3 fundamental principles of exercise physiology?
  63. 2 Methods to Determine Muscle Fiber Types
    myosin ATPase high in FT glycolytic, anaerobic fiber

    SDH high in ST fibers

    (light circle, dark circle) 50% ST oxidative - aerobic [SO, Type I, Red]

    (two dark circles) 30% FT high oxidative glycolytic [FOG, Type IIa, Intermediate]

    (dark circle, light circle) 20% FT glycolytic - anaerobic [FG, Type IIb, White]
  64. Rate of Contraction for Muscle Fiber Types
    (various physiological mechanism underlying the properties)
  65. Tension of Contraction for Muscle Fiber Types
    (various physiological mechanism underlying the properties)
  66. Endurance Properties for Muscle Fiber Types
    (various physiological mechanism underlying the properties)
  67. General Neuronal Characteristics of FT and ST Motor Units
  68. Contraction of ST and FT Motor Units
  69. Recruitment Characteristics of ST and FT Motor Units
  70. Size Principle
    motor units whose neurons have a smaller cell body (i.e., ST motor units) are generally recruited first followed by motor units whose neurons have a larger cell body (FT motor units).
  71. Which came first, the motor neuron or the fiber type?
    Cross-innervation studies indicate that "neurons dominate the response characteristics of the muscle tissue" due to either (theories) axoplasmic flow of a genetic substance theory or use-disuse theory.

    Although traditional thought suggested that ST fibers could not be converted to FT fibers and vice-versa; recent studies indicated that sprint training increase FT fibers and decreased ST fibers

    more research is needed to resolve the issue
  72. What do cross-innervation studies indicate?
    "neurons dominate the response characteristics of the muscle"
  73. What theories are used to explain the results of cross-innervation studies?
    2 Theories

    • (1) axoplasmic flow
    • (2) use-disuse

    "genetic substance"
  74. Distribution of Fiber Type
    Muscle fiber type composition for a muscle shows basically normal distribution in both men and women.
  75. Does the distribution of muscle fiber types vary between as well as within individuals? EXPLAIN
  76. Does the distribution of muscle fiber types relate to performance in various events? EXPLAIN
  77. Is successful performance in various events related to nature (genetics) and/or nurture (training)? EXPLAIN
  78. Determinants of Force Production
    1-5, 1-5A, 1-5B

    • A. Number of fibers within an active motor unit
    • B. Number of motor units activated within a muscle
    • C. Size of fibers within an active motor unit
    • D. Balance between stimulating (acetylcholine) and inhibition (GABA) neurotransmitters
    • E. Frequency of neural impulses
    • F. Synchronous, coordinated firing of motor units
    • G. Motor unit recruitment patterns
    • H. Speed of movement and fiber type
    • I. Initial length of the muscle fibers
    • J. Angle of pull
    • K. Architecture (configuration) of tendon and muscle fibers
  79. Various Effects of Fatigue on Force Production

    (1) Metabolic by-products, such as lactic acid accumulation from anaerobic glycolysis or the accumulation of ketone bodies from the breakdown of fatty acids in the absence of the needed carbohydrates to prime the pump for fat utilization, will decrease the pH of muscle tissue; a decrease in pH will interfere with Ca++ release from the sarcoplasmic reticulum, actin-myosin binding, and ATP breakdown for energy

    (2) Deletion of the neurotransmitter acetylcholine in the motor neuron axon terminal

    (3) Depletion of the intramuscular phosphagen stores 

    (4) A greater relative distribution of FT muscle fibers in the working muscles will result in an earlier onset of fatigue; FT muscle fibers (particularly FG) have much lower oxidative capabilities and consequently endurance capabilities than the ST oxidative muscle fibers and to a certain extent, the FOG muscle fibers
  80. Factors Influencing Speed of Movement

    (1) FT muscle fibers have faster speeds of movement capabilities than ST muscle fibers; consequently, an individual with a relatively high distribution of FT muscle fibers can potentially move at faster speeds of movement than an individual with a relatively high distribution of ST muscle fibers. About 25% of the difference in speed of movement capabilities can be attributed to amount of FT muscle fiber types

    (2) The greater the force production capabilities relative to resistance, the greater the potential speed of movement; similarly, the greater the force production capabilities relative to body weight, the greater the potential acceleration of the body and consequently, the greater the potential speed of movement. Hence, an increase in force production capabilities or a decrease in excess fat weight will increase the potential speed of movement.

    (3) The greater the coordination via synchronous recruitment of agonist and antagonist muscle groups, the greater the potential speed of movement.
  81. How does training affect contractile-related factors?
  82. How does training affect muscle fiber type composition?
  83. Does strength training compliment endurance training and does endurance training compliment strength training?
    1-8, 1-8A
  84. 3 Primary Sources of Fatigue
  85. How does fatigue affect force production?
  86. Is the rate of fatigue related to muscle fiber type? EXPLAIN
  87. Primary Factors Influencing Speed of Movement
  88. Anaerobic Metabolic Pathways
    Phosphagen or ATP-PC System

    Anaerobic Glycolytic

    Lactic Acid System
  89. Aerobic Metabolic Pathways
    Aerobic Glycolytic System

    Kreb's Cycle

    Beta or Fat Oxidative System

    Electron Transport System
  90. Key Substrates and Enzymes in Each Energy System or Cycle
    be able to match the substrates and enzymes with the correct cycle or system
  91. Factors Which Stimulate or Inhibit the Key Enzymes in Glycolysis
  92. Factors Which Stimulate or Inhibit the Rate of Glycolytic Activity
  93. *Which of the metabolic pathways are located in the sarcoplasm and mitochondria?

    • -phosphagen ATP-CP or alactate
    • -anaerobic glycolysis or lactic acid
    • -aerobic glycolysis or CHO oxidation STARTS in sarcoplasm
    • -beta (fat) oxidation TG's start in sarcoplasm


    • -aerobic glycolysis or CHO oxidation ENDS in mitochondria
    • -beta (fat) oxidation
    • -ETS inside inner membrane of mitochondria
  94. Glycogen Sparing
    citrate from inhibits PFK to slow down glycolysis to spare CHO to prime the pump for fat usage
  95. Priming the Pump for Fat Usage
    pyruvate converted to oxaloacetate to combine with acetyl CoA from fat to form citrate
  96. If carbohydrates (i.e., pyruvate) are not available to prime the pump for fat usage, the excess breakdown of fatty acids may result in the formation of what negative by-product?
  97. Does this negative by-product affect force production? How?
  98. 4 Ways ATP Can Be Synthesized
  99. How many net ATP can be synthesized from anaerobic glycolysis (lactic acid system) in skeletal and cardiac muscle?
    cardiac muscle = 38 ATP

    skeletal muscle = 36 ATP
  100. How many net ATP can be synthesized from aerobic glycolysis (CHO oxidation) in skeletal and cardiac muscle?
  101. For every molecule of acetyl CoA that enters the Krebs Cycle, how many ATP can be synthesized?
  102. How many ATP can be synthesized in the electron transport system if NAD and FAD carry the pairs of H+ and their associated electrons from glycolysis to the electron transport system?
  103. How many ATP can be synthesized in the electron transport system if NAD and FAD carry the pairs of H+ and their associated electrons from Krebs Cycle to the electron transport system?
  104. How many ATP can be synthesized in the electron transport system if NAD and FAD carry the pairs of H+ and their associated electrons from Beta Oxidation to the electron transport system?
  105. How many acetyl CoA molecules can be formed from a triglycerid molecule (assume all the fatty acids are either 12, 14, 16, or 18 carbons in length)?
  106. Other than the acetyl CoA fatty acids, what are two other sources of fuel substrate and/or ATP from fat metabolism?
  107. For each gram of fat and CHO, approximately how many kcal can be yielded?
  108. 4 Fates of Pyruvate
  109. Factors That Influence the Rate of Pyruvate
  110. Does training effect the factors influencing the fate of pyruvate? How?
  111. *Factors That Affect the Power (kcal/min) and Capacity (kcal) of the Various Energy Systems
    • Phosphagen ATP-CP
    • -myosin ATPase
    • -CPK (creatine phosphokinase)
    • -AK (adenylate kinase)

    • Anaerobic Glycolysis
    • -phosphorylase
    • -HK (hexokinase)
    • -PFK (phosphofructokinase)
    • -PK (pyruvate kinase)

    • Aerobic Glycolysis
    • -CS (citrate synthase)
    • -SDH (succinate dehydrogenase)
    • -O2
    • -ETS cytochromes
    • -kreb's cycle enzymes

    • Beta Oxidation
    • -lipase
    • -thiokinase
    • -thiolase
    • -O2
    • -ETS cytochromes
    • -kreb's cycle enzymes

    • ETS
    • -cytochromes
  112. General Metabolic Responses of the Energy Systems to Exercise
    At the onset of exercise, the energy system respond in the following order in reach steady state exercise:

    • (1) phosphagen metabolism
    • (2) anaerobic glycolysis
    • (3) oxidation metabolism
    • (3a) anaerobic glycolysis - CHO oxidation (moderate intensity)
    • (3b) beta oxidation (low intensity)
  113. *During what time frame is the phosphagen (ATP-PC) system the primary source of energy production during sustained maximal effort activities?
    12-15 seconds
  114. *During what time frame is the glycolytic system the primary source of energy production during sustained maximal effort activities?
    45-60 seconds
  115. *During what time frame is the oxidative energy system the primary source of energy production during sustained maximal effort activities?
    greater than 4 minutes
  116. Hormones that Influence the Mobilization of Fat From Adipose Tissue
    • Thyroxine
    • Cortisol
    • Glucagon
    • Epinephrine
    • Norepinephrine
    • Insulin - inhibits HSL (hormone sensistive lipase) & decreases fat mobilization
    • Caffeine - stimulates HSL (also stimulates phosphorylase in glycolysis)

    Exercise decreases insulin release from pancreas
  117. How Catecholamines Regulate Glycogenesis (breakdown of CHO) and Lipolysis (breakdown of fat) in Muscle Tissue
  118. Basic Principles of CHO Loading
    CHO Loading Prior to Exercise

    approximately 1-week prior to a major endurance event, perform a long workout to deplete the muscle glycogen stores. Then for the next 3 days eat a low CHO diet. Then, switch to a high CHO diet for the 3 days prior to the major endurance competition.

    CHO Fluid Ingestion During Exercise

    During exercise, drink 4-8 ounces of cold water every 10-15 minutes containing a 5-10% glucose concentration.

    Both CHO loading prior to exercise and the ingestion of CHO fluids during exercise will significantly increase muscle glycogen levels thereby enhancing performance during moderate intensity, long duration exercise. The capacity of aerobic glycolysis will be increased as well as the capacity of fat oxidation due to an increase in muscle glycogen which is also needed to prime the pump for fat utilization.
  119. Does CHO loading enhance sprint and endurance performance? Why?
    Recent research indicates that CHO loading prior to high intensity, short duration exercise enhances performance by increasing work time to exhaustion before fatigue occurs.

    Recent research also indicates that CHO fluid ingestion will enhance intermittent high intensity exercise performance by increasing work time to exhaustion before fatigue occurs.

    This type of intermittent high intensity exercise is similar to what is experienced by athletes in sports such as basketball, soccer and hockey. During high intensity, short duration exercise, CHO loading prior to exercise and CHO fluid ingestion during exercise appears to enhance CHO availability and hence anaerobic work capabilities.
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Exercise Physio LECTURE 1.txt