Toxic effects of mixed-drug overdose (especially tricyclics).
Flumazenil (Romazicon)
How supplied
5 and 10 mL vials (0.1mg/mL).
Flumazenil (Romazicon)
Dosage and administration
Adult: First dose: 0.2mg IV/IO over 15 seconds.
second dose: 0.3mg IV/IO over 30 seconds. if no reponse, give third dose.
third dose: 0.5mg IV/IO over 30 seconds. if no reponse, repeat once every minute until adequate reponse or a total of 3mg is given.
Pediatric: Not recommended.
Flumazenil (Romazicon)
Duration of Action
Onset: 1-2 minutes.
Peak effect and duration related to plasma concentration of benzodiazepines.
Flumazenil (Romazicon)
Special considerations
Pregnancy safety: Category C. Be prepared to manage seizures in Pts. wha are physically dependent on benzodiazepines or who have ingested large doses of other drugs. Romazicon may precipitate withdrawal syndromes in pts. dependent on benzodiazepines. Monitor Pts. for re-sedation and repiratory depression. Be prepared to assist ventilations.