Antineoplastics

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  1. Alkylating Agents
    Chlorambucil

    Take w/Mesna (↓ hemorr cystitis)

    No oral anticoagulants
  2. Antimetabolites
    Methotrexate

    • "Leukovorin rescue"
    • - 5-FU (potentiates
    • - MTX (child-sarcoma)

    Treats rheumatoid arthitis

    Photosensitivity (dark veins); ulcerative stomatitis
  3. Antineoplastic Antibiotic
    Doxorubicin

    AIDS related kaposi sarcoma, breast & testicular cancer

    Cardiac & pulmonary toxicity
  4. Protein Mitotic Inhibitor
    Vincristine

    Rhabdomyosarcoma

    D/D inject intrathecally

    Neurotoxic
  5. Hormone modulators
    Tamoxifen

    • Estrogen (block receptor site for hormone)
    • breast cancer

    Hot flashes, hypercalcemia, cario disease & accident
  6. Protein Tyrosine Kinase Inhibitor
    Imatinib

    • CML (leukemia)
    • GIST (gastro strom)
  7. Epidermal Growth Factors
    Erbtinib

    NSCLC  (non small cell lung cancer)

    Limited use toxic
  8. Proteasome Inhibitors
    Bortezomib

    Multiple Myeloma
Author
ID
253698
Card Set
Antineoplastics
Description
Antineoplastics/Cancer cell specific drugs
Updated
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