pharm simple antiangina

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  1. 3 types of drugs to treat angina
    • organic nitrates¬†
    • beta blockers
    • Ca++ channel blockers
  2. drug types that decrease O2 demand
    • organic nitrates
    • beta blockers
  3. drug type that increases O2 supply
    Ca++ blocker
  4. organic nitrates - basically, what do they do?
    dilate vascular smooth muscle --> decreases the amount of work the heart must perform --> decreases myocardial O2 demand
  5. 2 organic nitrate drugs
    • nitroglycerin
    • isosorbide dinitrate
  6. nitrates are drug precursors that become active when converted to __ within __
    • nitrous oxide
    • vascular smooth muscle
  7. nitroglycerin
    • a nitrate
    • causes vasodilation
  8. nitroglycerin - admin how? list in order from fastest to slowest impact
    sublingual, buccal, oral, transdermal
  9. isosorbide dinitrate
    • a nitrate
    • causes vasodilation
    • lasts longer than nitroglycerin
  10. to treat stable angina, use what types of drugs?
    • beta blockers and organic nitrates
    • Ca++ channel blockers too, but they only impact the myocardium and periph vasculature -- they don't dilate coronary arteries
  11. what kinds of meds to use for variant angina?
    • Ca++ channel blockers
    • (nitrates can be used for severe forms)
  12. unstable angina - use what drug types?
    determined pt by pt
  13. beta-adrenergic blockers - basically, do what?
    decrease HR and force of contraction --> decreases the heart's workload --> decreases O2 demande
  14. 2 beta blockers
    • atenolol
    • netoprolol
  15. calcium channel blockers - basically, do what?
    relax and dilate the blood vessels
  16. 2 calcium channel blockers
    • diltiazem
    • nifedipine
  17. atenolol and metoprolol are what type of drug?
    beta-blockers (decrease O2 demand by decreasing heart workload)
  18. diltiazem and nifedipine are what type of drug?
    calcium channel blockers (relax/dilate blood vessels)
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pharm simple antiangina
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