Viral Hepatitis

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  1. which hepatitis does not exist by itself and which hepatitis does it coexist with
    hep B does not exist by itself, coexists with B
  2. which hepatitis virus is located in feces
    A and E
  3. which hepatitis is located in the blood/blood-derived body fluids
  4. what is the route of transmission for A and E
  5. what is the mode of transmission for hep B, C, D
    • percutaneous 
    • permucosal
  6. which hepatitis virus is chronic
    B, C, D
  7. which hepatitis virus does not have immunization
    C, and E
  8. acute hepatitis viruses
    A, E
  9. avg incubation period for hep A
    30 days (range 15-50)
  10. when would a person with hep A be allowed  to return to school
    • 1 wk after sx
    • -not contagious 2wks before and 1 wk after sx
  11. how is hep A acute infection diagnosed
    HAV-IgM in serum by EIA
  12. which is not a mode of transmission for Hep A
    blood exposure
  13. time frame for post exposure
    within 14 days
  14. avg incubation period for Hep B
    60-90 days
  15. which vaccinations does new born babies get along with silver nitrate
    Hep B
  16. which hepatitis viruses can cause cancer and cirrhosis
    hep B and C
  17. what is the acute window period for hepatits virus
    period when on HCcAG is detected by itself
  18. what is HBsAG
    the actual antigen
  19. what is HBeAg
    multiplication part of virus
  20. what is HBcAg
    part of the antigen (core antigen)
  21. what does HBsAb indicate
    immunity to HBV and protection from disease
  22. what does HBcAb indicate
    past or active infection; present whether the person is immune or chronic carrier
  23. what does IgM indicate
    early indicator of acute infection
  24. what does HBeAg indicate
    person is highly infections
  25. which hepatitis infections are difficult to treat
  26. which serological marker is prone to false positives
  27. HBcAb
  28. hepatitis B have high concentrations in which body fluids
    • blood
    • serum
    • wound exudates
  29. modes of transmission for hep b
    • sexual
    • parenteral
    • perinatal
  30. Tx for HBV
    • lamuvidine and INF (initially)
    • adefovir/entecavir (later)
  31. complications that arise from HBV
    • arthritis
    • glomerulonephritis
    • polyarteritis nodosa
    • hepatocellular carcinoma
  32. transmission of HDV
    parenteral (IV drug use mostly)
  33. what is the incubation time of HDV
    similar to HBV; 60 days
  34. tx of HDV
    • same as HBV;
    • lamuvidine
    • INF 
    • adefovir
    • entecavir
  35. transmission of HCV
    • blood transfusion 
    • IV drug abuse
    • intranasal cocaine use
    • piercing
  36. most resistant/difficult type of HCV to tx
    type 1
  37. incubation period for HCV
    6-7 wks
  38. percentage of chronic hepatitis for HCV pts
  39. HCV is not spread by
    • casual contact;
    • hugging/kissing
    • shaking hands
    • sitting on a toilet seat
  40. tx for acute HCV
    INF alpha
  41. tx for chronic HCV
    INF alpha/peginterferon + ribavirin
  42. which INF is used for HCV type I
  43. what are the complications for HCV
    • cryoplobulinemia
    • membranoproliferative glomerulonephritis
    • hepatocellular carcinoma
    • cirrhosis
  44. contraindications of INF-alpha
    major depression and organ transplant
  45. ribavirin contraindications
  46. incubation period for HEV
    40 days
  47. what is the case fatality rate for pregnant women with HEV
  48. monitoring for pt on therapy to assess response to tx
    • q 3 months on oral agents
    • q 1 month on PEGINF
  49. monitoring for pts off therapy to estimate prognosis and to evaluate need for tx
    every 6 - 12 months
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Viral Hepatitis
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