Axonal Transport and Motor Proteins

• there are plus and minus end directed motor proteins:
• kinesin: plus end
• cytoplasmic dynein: minus end

allows swift exchange of substances between the nerve cell body and the synaptic terminal at which the nerve fiber adjoins its target cell

that will convey NT are manufactured by the Golgi and carried toward the synapse

at the synaptic terminal is packaged into multivesicular bodies, which return to lysosomes in the cell body for degradation

move in both directions, catering to the energy demands of the cell

• continuous
• intermittent
• False: both directioned

there can be side arms projecting and ATPase is responsible for energy

going away from the cell body

hydrolyze atp

ADP to leave and ATP to bind. It is then hydrolyzed

changes in shape of the head area

bind to transported vesicles

coontraction

• kinetochore microtubules were depolymerizing at the centromere and being added to the centromere 
• problem: no driving force

• kinetochore microtubules slide along polar microtubules
• problem: doesn't account for shortening or lengteniing

someone suggested an elastic material int he spindle that shortened and pulled

not elastic material but some interaction between actin and MT

• kin MT does get shorter at the kinetochore end, not centrosome end
• evidence: in newt, movemvent of chromosomes was 50 dimers lost per second

• -region of force is the kinetochore end
• -kinetochore microtubule is stationery but is losing dimers